Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

M Vallet-Regí, F Schüth, D Lozano, M Colilla… - Chemical Society …, 2022 - pubs.rsc.org
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …

[Retracted] U‐Net‐Based Medical Image Segmentation

XX Yin, L Sun, Y Fu, R Lu… - Journal of healthcare …, 2022 - Wiley Online Library
Deep learning has been extensively applied to segmentation in medical imaging. U‐Net
proposed in 2015 shows the advantages of accurate segmentation of small targets and its …

Nanomedicine tumor targeting

T Lammers - Advanced Materials, 2024 - Wiley Online Library
Nanomedicines are extensively explored for cancer therapy. By delivering drug molecules
more efficiently to pathological sites and by attenuating their accumulation in healthy organs …

Smart cancer nanomedicine

R van der Meel, E Sulheim, Y Shi, F Kiessling… - Nature …, 2019 - nature.com
Nanomedicines are extensively employed in cancer therapy. We here propose four strategic
directions to improve nanomedicine translation and exploitation.(1) Patient stratification has …

Polymersome-based protein drug delivery–quo vadis?

MG Gouveia, JP Wesseler, J Ramaekers… - Chemical Society …, 2023 - pubs.rsc.org
Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …

Quantifying the ligand-coated nanoparticle delivery to cancer cells in solid tumors

Q Dai, S Wilhelm, D Ding, AM Syed, S Sindhwani… - ACS …, 2018 - ACS Publications
Coating the nanoparticle surface with cancer cell recognizing ligands is expected to facilitate
specific delivery of nanoparticles to diseased cells in vivo. While this targeting strategy is …

Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

AR Rastinehad, H Anastos, E Wajswol… - Proceedings of the …, 2019 - pnas.org
Biocompatible gold nanoparticles designed to absorb light at wavelengths of high tissue
transparency have been of particular interest for biomedical applications. The ability of such …

Mechanisms and barriers in nanomedicine: progress in the field and future directions

T Anchordoquy, N Artzi, IV Balyasnikova, Y Barenholz… - ACS …, 2024 - ACS Publications
In recent years, steady progress has been made in synthesizing and characterizing
engineered nanoparticles, resulting in several approved drugs and multiple promising …

Alliance with EPR effect: combined strategies to improve the EPR effect in the tumor microenvironment

J Park, Y Choi, H Chang, W Um, JH Ryu… - Theranostics, 2019 - pmc.ncbi.nlm.nih.gov
The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …

Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

J Li, K Kataoka - Journal of the American Chemical Society, 2020 - ACS Publications
The past few decades have witnessed an evolution of nanomedicine from biologically inert
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …