Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …

Heart failure (HF) with preserved ejection fraction (HFpEF) is a multifactorial disease
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …

Exercise training has been widely recognized as a healthy lifestyle as well as an effective
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …

Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond
to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and …

The natural aging process is carried out by a progressive loss of homeostasis leading to a
functional decline in cells and tissues. The accumulation of these changes stem from a …

Growing evidence has demonstrated exercise as an effective way to promote cardiovascular
health and protect against cardiovascular diseases However, the underlying mechanisms of …

Conclusions The CF has recently emerged as one of the most phenotypically plastic cells in
the heart, with distinct transcriptional and secretory programs that regulate their essential …

Age-related blood-brain barrier (BBB) disruption and cerebromicrovascular rarefaction
contribute importantly to the pathogenesis of both vascular cognitive impairment and …

Acute and chronic animal models of exercise are commonly used in research. Acute
exercise testing is used, often in combination with genetic, pharmacological, or other …