High-end ion mobility mass spectrometry: A current review of analytical capacity in omics applications and structural investigations

DG Delafield, G Lu, CJ Kaminsky, L Li - TrAC Trends in Analytical …, 2022 - Elsevier
Mass spectrometry-based biomolecular analyses have become permanent fixtures of
academic, industrial, and clinical research settings. The rise in utilization of mass …

Identification of splice variants and isoforms in transcriptomics and proteomics

T Su, MAR Hollas, RT Fellers… - Annual review of …, 2023 - annualreviews.org
Alternative splicing is pivotal to the regulation of gene expression and protein diversity in
eukaryotic cells. The detection of alternative splicing events requires specific omics …

Applications of tandem mass spectrometry (MS/MS) in protein analysis for biomedical research

AN Neagu, M Jayathirtha, E Baxter, M Donnelly… - Molecules, 2022 - mdpi.com
Mass Spectrometry (MS) allows the analysis of proteins and peptides through a variety of
methods, such as Electrospray Ionization-Mass Spectrometry (ESI-MS) or Matrix-Assisted …

[HTML][HTML] Considerations for constructing a protein sequence database for metaproteomics

JA Blakeley-Ruiz, M Kleiner - Computational and structural biotechnology …, 2022 - Elsevier
Mass spectrometry-based metaproteomics has emerged as a prominent technique for
interrogating the functions of specific organisms in microbial communities, in addition to total …

Optimizing single cell proteomics using trapped ion mobility spectrometry for label-free experiments

DG Mun, FA Bhat, H Ding, BJ Madden, S Natesampillai… - Analyst, 2023 - pubs.rsc.org
Although single cell RNA-seq has had a tremendous impact on biological research, a
corresponding technology for unbiased mass spectrometric analysis of single cells has only …

Proteomics of the Heart

OA Karpov, A Stotland, K Raedschelders… - Physiological …, 2024 - journals.physiology.org
Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …

[PDF][PDF] Necroptosis is associated with Rab27‐independent expulsion of extracellular vesicles containing RIPK3 and MLKL

K Gupta, KA Brown, ML Hsieh… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicle (EV) secretion is an important mechanism used by cells to release
biomolecules. A common necroptosis effector—mixed lineage kinase domain like (MLKL) …

An overview of technologies for MS-based proteomics-centric multi-omics

AT Rajczewski, PD Jagtap, TJ Griffin - Expert review of proteomics, 2022 - Taylor & Francis
Introduction Mass spectrometry-based proteomics reveals dynamic molecular signatures
underlying phenotypes reflecting normal and perturbed conditions in living systems …

One-pot exosome proteomics enabled by a photocleavable surfactant

KM Buck, DS Roberts, TJ Aballo, DR Inman… - Analytical …, 2022 - ACS Publications
Exosomes are small extracellular vesicles (EVs) secreted by all cells and found in biological
fluids, which can serve as minimally invasive liquid biopsies with extremely high therapeutic …

Digital Microfluidics for Microproteomic Analysis of Minute Mammalian Tissue Samples Enabled by a Photocleavable Surfactant

C Chan, J Peng, V Rajesh, EY Scott… - Journal of Proteome …, 2023 - ACS Publications
Proteome profiles of precious tissue samples have great clinical potential for accelerating
disease biomarker discovery and promoting novel strategies for early diagnosis and …