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Vimentin is at the heart of epithelial mesenchymal transition (EMT) mediated metastasis
Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …
functional support to the cell. During initial stages of cancer development, vimentin …
Cytoskeletal crosstalk in cell migration
Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly
comprises the actin microfilaments, microtubules, and intermediate filaments. During …
comprises the actin microfilaments, microtubules, and intermediate filaments. During …
Vimentin and cytokeratin: Good alone, bad together
The cytoskeleton plays an integral role in maintaining the integrity of epithelial cells.
Epithelial cells primarily employ cytokeratin in their cytoskeleton, whereas mesenchymal …
Epithelial cells primarily employ cytokeratin in their cytoskeleton, whereas mesenchymal …
[HTML][HTML] Vimentin intermediate filaments as potential target for cancer treatment
K Strouhalova, M Přechová, A Gandalovičová… - Cancers, 2020 - mdpi.com
Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …
Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation
CY Liu, HH Lin, MJ Tang, YK Wang - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
Modulations of cytoskeletal organization and focal adhesion turnover correlate to
tumorigenesis and epithelial-mesenchymal transition (EMT), the latter process accompanied …
tumorigenesis and epithelial-mesenchymal transition (EMT), the latter process accompanied …
The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration
DD Tang, BD Gerlach - Respiratory research, 2017 - Springer
Smooth muscle cell migration has been implicated in the development of respiratory and
cardiovascular systems; and airway/vascular remodeling. Cell migration is a polarized …
cardiovascular systems; and airway/vascular remodeling. Cell migration is a polarized …
Vimentin diversity in health and disease
F Danielsson, MKK Peterson, H Caldeira Araújo… - Cells, 2018 - mdpi.com
Vimentin is a protein that has been linked to a large variety of pathophysiological conditions,
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …
Vimentin in cancer and its potential as a molecular target for cancer therapy
A Satelli, S Li - Cellular and molecular life sciences, 2011 - Springer
Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously
expressed in normal mesenchymal cells and is known to maintain cellular integrity and …
expressed in normal mesenchymal cells and is known to maintain cellular integrity and …
Vimentin: Regulation and pathogenesis
Vimentin, an abundant cytoplasmic intermediate filament protein, is recognized for its
important role in stabilizing intracellular structure. Vimentin has been recognized for its …
important role in stabilizing intracellular structure. Vimentin has been recognized for its …
Post-translational modifications of intermediate filament proteins: mechanisms and functions
NT Snider, MB Omary - Nature reviews Molecular cell biology, 2014 - nature.com
Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-co** resilience to cells, contribute to subcellular and tissue-specific …
mechanical and stress-co** resilience to cells, contribute to subcellular and tissue-specific …