Vimentin is at the heart of epithelial mesenchymal transition (EMT) mediated metastasis

S Usman, NH Waseem, TKN Nguyen, S Mohsin… - Cancers, 2021 - mdpi.com
Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …

Cytoskeletal crosstalk in cell migration

S Seetharaman, S Etienne-Manneville - Trends in cell biology, 2020 - cell.com
Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly
comprises the actin microfilaments, microtubules, and intermediate filaments. During …

Vimentin and cytokeratin: Good alone, bad together

NA Kuburich, P den Hollander, JT Pietz… - Seminars in cancer …, 2022 - Elsevier
The cytoskeleton plays an integral role in maintaining the integrity of epithelial cells.
Epithelial cells primarily employ cytokeratin in their cytoskeleton, whereas mesenchymal …

[HTML][HTML] Vimentin intermediate filaments as potential target for cancer treatment

K Strouhalova, M Přechová, A Gandalovičová… - Cancers, 2020 - mdpi.com
Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin
and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of …

Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation

CY Liu, HH Lin, MJ Tang, YK Wang - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
Modulations of cytoskeletal organization and focal adhesion turnover correlate to
tumorigenesis and epithelial-mesenchymal transition (EMT), the latter process accompanied …

The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration

DD Tang, BD Gerlach - Respiratory research, 2017 - Springer
Smooth muscle cell migration has been implicated in the development of respiratory and
cardiovascular systems; and airway/vascular remodeling. Cell migration is a polarized …

Vimentin diversity in health and disease

F Danielsson, MKK Peterson, H Caldeira Araújo… - Cells, 2018 - mdpi.com
Vimentin is a protein that has been linked to a large variety of pathophysiological conditions,
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …

Vimentin in cancer and its potential as a molecular target for cancer therapy

A Satelli, S Li - Cellular and molecular life sciences, 2011 - Springer
Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously
expressed in normal mesenchymal cells and is known to maintain cellular integrity and …

Vimentin: Regulation and pathogenesis

D Paulin, A Lilienbaum, S Kardjian, O Agbulut, Z Li - Biochimie, 2022 - Elsevier
Vimentin, an abundant cytoplasmic intermediate filament protein, is recognized for its
important role in stabilizing intracellular structure. Vimentin has been recognized for its …

Post-translational modifications of intermediate filament proteins: mechanisms and functions

NT Snider, MB Omary - Nature reviews Molecular cell biology, 2014 - nature.com
Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-co** resilience to cells, contribute to subcellular and tissue-specific …