Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease

AC Müller-Nedebock, MCJ Dekker, MJ Farrer… - npj Parkinson's …, 2023 - nature.com
The biological basis of the neurodegenerative movement disorder, Parkinson's disease
(PD), is still unclear despite it being 'discovered'over 200 years ago in Western Medicine …

Structural MRI of brain similarity networks

I Sebenius, L Dorfschmidt, J Seidlitz… - Nature Reviews …, 2024 - nature.com
Recent advances in structural MRI analytics now allow the network organization of
individual brains to be comprehensively mapped through the use of the biologically …

Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson's disease model

NLG Del Rey, N Hernández-Pinedo, M Carrillo… - npj Parkinson's …, 2024 - nature.com
The differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta
(SNc) is a critical and unresolved question in Parkinson´ s disease. Studies in mice show …

Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in …

S Pyatha, H Kim, D Lee, K Kim - Frontiers in Public Health, 2023 - frontiersin.org
Humans are exposed to lead (Pb), mercury (Hg), and cadmium (Cd) through various routes,
including drinking water, and such exposure can lead to a range of toxicological effects …

From active affordance to active inference: vertical integration of cognition in the cerebral cortex through dual subcortical control systems

P Luu, DM Tucker, K Friston - Cerebral Cortex, 2024 - academic.oup.com
In previous papers, we proposed that the dorsal attention system's top-down control is
regulated by the dorsal division of the limbic system, providing a feedforward or impulsive …

Neuroplasticity in Parkinson's disease

BO Popescu, L Batzu, PJG Ruiz, D Tulbă… - Journal of Neural …, 2024 - Springer
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, affecting
millions of people and rapidly increasing over the last decades. Even though there is no …

Brain-biomarker changes in body fluids of patients with Parkinson's disease

C Cocco, AL Manai, E Manca, B Noli - International Journal of Molecular …, 2023 - mdpi.com
Parkinson's disease (PD) is an incurable neurodegenerative disease that is rarely
diagnosed at an early stage. Although the understanding of PD-related mechanisms has …

[HTML][HTML] Tunneling Nanotube: An Enticing Cell–Cell Communication in the Nervous System

S Dagar, S Subramaniam - Biology, 2023 - mdpi.com
Simple Summary This review highlights the role of tunneling nanotubes (TNTs) and TNT-like
structures in the nervous system. TNTs are thin, hollow plasma membrane projections that …

Cortical type: a conceptual tool for meaningful biological interpretation of high-throughput gene expression data in the human cerebral cortex

A Sancha-Velasco, A Uceda-Heras… - Frontiers in …, 2023 - frontiersin.org
The interpretation of massive high-throughput gene expression data requires computational
and biological analyses to identify statistically and biologically significant differences …

Expansion modes of primate nervous system structures in the light of the Prosomeric Model

S Ruiz-Cabrera, I Pérez-Santos… - Frontiers in Mammal …, 2023 - frontiersin.org
The expansion of human and non-human primate central nervous system structures has
been a paramount question for classic and contemporary studies in comparative vertebrate …