Microfluidics for drug development: from synthesis to evaluation
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …
delivery, and drug evaluation. Compared with conventional drug development procedures …
[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …
human physiopathology with striking discrepancies in estimating drug efficacy and side …
Recent advances for cancer detection and treatment by microfluidic technology, review and update
N Bargahi, S Ghasemali, S Jahandar-Lashaki… - Biological Procedures …, 2022 - Springer
Numerous cancer-associated deaths are owing to a lack of effective diagnostic and
therapeutic approaches. Microfluidic systems for analyzing a low volume of samples offer a …
therapeutic approaches. Microfluidic systems for analyzing a low volume of samples offer a …
Spheroid engineering in microfluidic devices
Two-dimensional (2D) cell culture techniques are commonly employed to investigate
biophysical and biochemical cellular responses. However, these culture methods, having …
biophysical and biochemical cellular responses. However, these culture methods, having …
[HTML][HTML] On-chip modeling of tumor evolution: Advances, challenges and opportunities
C Li, JB Holman, Z Shi, B Qiu, W Ding - Materials Today Bio, 2023 - Elsevier
Tumor evolution is the accumulation of various tumor cell behaviors from tumorigenesis to
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …
Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices
Microfluidics is an interdisciplinary field that encompasses both science and engineering,
which aims to design and fabricate devices capable of manipulating extremely low volumes …
which aims to design and fabricate devices capable of manipulating extremely low volumes …
Fabrication of a low-cost microfluidic device for high-throughput drug testing on static and dynamic cancer spheroid culture models
TD Do, UT Pham, LP Nguyen, TM Nguyen, CN Bui… - Diagnostics, 2023 - mdpi.com
Drug development is a complex and expensive process from new drug discovery to product
approval. Most drug screening and testing rely on in vitro 2D cell culture models; however …
approval. Most drug screening and testing rely on in vitro 2D cell culture models; however …
[HTML][HTML] From cell spheroids to vascularized cancer organoids: Microfluidic tumor-on-a-chip models for preclinical drug evaluations
Chemotherapy is one of the most effective cancer treatments. Starting from the discovery of
new molecular entities, it usually takes about 10 years and 2 billion US dollars to bring an …
new molecular entities, it usually takes about 10 years and 2 billion US dollars to bring an …
[HTML][HTML] Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro
T Collins, E Pyne, M Christensen, A Iles, N Pamme… - …, 2021 - pubs.aip.org
The majority of cancer deaths are linked to tumor spread, or metastasis, but 3D in vitro
metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) …
metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) …
Rapid prototy** of PMMA-based microfluidic spheroid-on-a-chip models using micromilling and vapour-assisted thermal bonding
The application of microfluidic devices as next-generation cell and tissue culture systems
has increased impressively in the last decades. With that, a plethora of materials as well as …
has increased impressively in the last decades. With that, a plethora of materials as well as …