Synthetic biology tools to engineer microbial communities for biotechnology

NS McCarty, R Ledesma-Amaro - Trends in biotechnology, 2019 - cell.com
Microbial consortia have been used in biotechnology processes, including fermentation,
waste treatment, and agriculture, for millennia. Today, synthetic biologists are increasingly …

The community-function landscape of microbial consortia

A Sanchez, D Bajic, J Diaz-Colunga, A Skwara… - Cell Systems, 2023 - cell.com
Quantitatively linking the composition and function of microbial communities is a major
aspiration of microbial ecology. Microbial community functions emerge from a complex web …

Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance

JSL Yu, C Correia-Melo, F Zorrilla… - Nature …, 2022 - nature.com
Microbial communities are composed of cells of varying metabolic capacity, and regularly
include auxotrophs that lack essential metabolic pathways. Through analysis of auxotrophs …

Programmable living assembly of materials by bacterial adhesion

B Chen, W Kang, J Sun, R Zhu, Y Yu, A **a… - Nature chemical …, 2022 - nature.com
The field of engineered living materials aims to construct functional materials with desirable
properties of natural living systems. A recent study demonstrated the programmed self …

Predictive biology: modelling, understanding and harnessing microbial complexity

AJ Lopatkin, JJ Collins - Nature Reviews Microbiology, 2020 - nature.com
Predictive biology is the next great chapter in synthetic and systems biology, particularly for
microorganisms. Tasks that once seemed infeasible are increasingly being realized such as …

Microbial interactions within the cheese ecosystem and their application to improve quality and safety

B Mayo, J Rodríguez, L Vázquez, AB Flórez - Foods, 2021 - mdpi.com
The cheese microbiota comprises a consortium of prokaryotic, eukaryotic and viral
populations, among which lactic acid bacteria (LAB) are majority components with a …

Environmental microbiome engineering for the mitigation of climate change

MR Silverstein, D Segrè… - Global Change …, 2023 - Wiley Online Library
Environmental microbiome engineering is emerging as a potential avenue for climate
change mitigation. In this process, microbial inocula are introduced to natural microbial …

[HTML][HTML] Toward merging bottom–up and top–down model-based designing of synthetic microbial communities

D San León, J Nogales - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Analysis and designing of microbiomes have become a new paradigm in
microbiology.•Understanding and rational engineering of microbiomes require model-based …

[HTML][HTML] Metabolic modelling approaches for describing and engineering microbial communities

B García-Jiménez, J Torres-Bacete… - Computational and …, 2021 - Elsevier
Microbes do not live in isolation but in microbial communities. The relevance of microbial
communities is increasing due to growing awareness of their influence on a huge number of …

[HTML][HTML] Computational modeling of metabolism in microbial communities on a genome-scale

AV Colarusso, I Goodchild-Michelman, M Rayle… - Current Opinion in …, 2021 - Elsevier
Computational modeling of microbial communities using GEnome-scale Models (GEMs) of
metabolism is a new frontier in systems biology. Here, we discuss recent developments in …