DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

DNA origami: scaffolds for creating higher order structures

F Hong, F Zhang, Y Liu, H Yan - Chemical reviews, 2017 - ACS Publications
DNA has become one of the most extensively used molecular building blocks for
engineering self-assembling materials. DNA origami is a technique that uses hundreds of …

Metal sensing by DNA

W Zhou, R Saran, J Liu - Chemical reviews, 2017 - ACS Publications
Metal ions are essential to many chemical, biological, and environmental processes. In the
past two decades, many DNA-based metal sensors have emerged. While the main …

Building machines with DNA molecules

H Ramezani, H Dietz - Nature Reviews Genetics, 2020 - nature.com
In nature, DNA molecules carry the hereditary information. But DNA has physical and
chemical properties that make it attractive for uses beyond heredity. In this Review, we …

Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation

J Li, AA Green, H Yan, C Fan - Nature chemistry, 2017 - nature.com
Nucleic acids have attracted widespread attention due to the simplicity with which they can
be designed to form discrete structures and programmed to perform specific functions at the …

Concept and development of framework nucleic acids

Z Ge, H Gu, Q Li, C Fan - Journal of the American Chemical …, 2018 - ACS Publications
The blooming field of structural DNA nanotechnology harnessing the material properties of
nucleic acids has attracted widespread interest. The exploitation of the precise and …

Single-stranded DNA and RNA origami

D Han, X Qi, C Myhrvold, B Wang, M Dai, S Jiang… - Science, 2017 - science.org
INTRODUCTION Self-folding of an information-carrying polymer into a compact particle with
defined structure and function (for example, folding of a polypeptide into a protein) is …

Challenges and opportunities for structural DNA nanotechnology

AV Pinheiro, D Han, WM Shih, H Yan - Nature nanotechnology, 2011 - nature.com
DNA molecules have been used to build a variety of nanoscale structures and devices over
the past 30 years, and potential applications have begun to emerge. But the development of …

Programmable chemical controllers made from DNA

YJ Chen, N Dalchau, N Srinivas, A Phillips… - Nature …, 2013 - nature.com
Biological organisms use complex molecular networks to navigate their environment and
regulate their internal state. The development of synthetic systems with similar capabilities …

The emerging field of RNA nanotechnology

P Guo - Nature nanotechnology, 2010 - nature.com
Like DNA, RNA can be designed and manipulated to produce a variety of different
nanostructures. Moreover, RNA has a flexible structure and possesses catalytic functions …