Lysosomes are organelles containing acidic hydrolases that are responsible for lysosomal
degradation and the maintenance of cellular homeostasis. They play an important role in …

Cyclic nucleotide phosphodiesterases (PDEs) are superfamily of enzymes that regulate the
spatial and temporal relationship of second messenger signaling in the cellular system …

Background Cationic amphiphilic antihistamines have been shown to improve patient
outcomes in immunogenic tumours, but whether they can augment and improve response to …

Alzheimer's disease (AD) and Parkinson's disease (PD) represent the most prevalent
neurodegenerative disorders severely impacting life expectancy and quality of life of millions …

Small interfering RNAs (siRNAs) are promising therapeutics for the treatment of human
diseases via the induction of sequence-specific gene silencing. To be functional, siRNAs …

Repair of damaged plasma membrane in eukaryotic cells is largely dependent on the
binding of annexin repair proteins to phospholipids. Changing the biophysical properties of …

Being originally discovered as cellular recycling bins, lysosomes are today recognized as
versatile signaling organelles that control a wide range of cellular functions that are …

The priority list of freshwater pollutants is increasingly amended by pharmaceuticals. Their
impact on the aquatic biota can be modulated by the presence of typical pollutants, like …

It is increasingly appreciated that ion channels have a crucial role in tumors, either as
promoters of cancer cell growth, or modulators of immune cell functions, or both. Among ion …

The transcription factor cyclic-AMP response element-binding protein 1 (CREB1) responds
to cAMP level and controls the expression of target genes, which regulates nutrition …