Since the first pioneering studies on small deuterated peptides dating more than 20 years
ago, 1H detection has evolved into the most efficient approach for investigation of …

Membrane proteins reside at interfaces between aqueous and lipid media and solving their
molecular structure relies most of the time on removing them from the membrane using …

Protein structures at solid/liquid interfaces mediate interfacial protein functions, which are
important for many applications. It is difficult to probe interfacial protein structures at buried …

In the last 20 years, the use of electron paramagnetic resonance (EPR) has made a
pronounced and lasting impact in the field of structural biology. The advantage of EPR …

The voltage-dependent anion channel (VDAC), the most abundant protein in the outer
mitochondrial membrane, is responsible for the transport of all ions and metabolites into and …

Benefitting from the rapid evolution of artificial intelligence and structural biology, an
expanding collection of high-resolution protein structures has greatly improved our …

Chromatin phase separation is dynamically regulated by many factors, such as post-
translational modifications and effector proteins, and plays a critical role in genomic …

The currently circulating S31N variant of the M2 proton channel of influenza A is resistant to
antiviral drugs. Recently, there has been a growing concern regarding the impact of the lipid …

The 97-residue influenza A matrix 2 (ΑM2) protein, a prototype for viroporins, transports
protons through water molecules and His37. We discuss structural biology and molecular …

This report investigates the homotetrameric membrane protein structure of the S31N M2
protein from Influenza A virus in the presence of a high molar ratio of lipid. The structured …