Mechanisms of mitophagy
Autophagy not only recycles intracellular components to compensate for nutrient deprivation
but also selectively eliminates organelles to regulate their number and maintain quality …
but also selectively eliminates organelles to regulate their number and maintain quality …
What genetics tells us about the causes and mechanisms of Parkinson's disease
O Corti, S Lesage, A Brice - Physiological reviews, 2011 - journals.physiology.org
Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Parkinson's disease is the most common neurodegenerative movement disorder. Mutations
in PINK1 and PARKIN are the most frequent causes of recessive Parkinson's disease …
in PINK1 and PARKIN are the most frequent causes of recessive Parkinson's disease …
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
N Exner, AK Lutz, C Haass, KF Winklhofer - The EMBO journal, 2012 - embopress.org
Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …
biochemical, and physiological features. They are characterized by high rates of metabolic …
[HTML][HTML] Mitochondrial dysfunction in Parkinson's disease
KF Winklhofer, C Haass - Biochimica et Biophysica Acta (BBA)-Molecular …, 2010 - Elsevier
Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to
their prominent role in energy metabolism, mitochondria are intimately involved in various …
their prominent role in energy metabolism, mitochondria are intimately involved in various …
Role of manganese in neurodegenerative diseases
Manganese (Mn) is an essential ubiquitous trace element that is required for normal growth,
development and cellular homeostasis. Exposure to high Mn levels causes a clinical …
development and cellular homeostasis. Exposure to high Mn levels causes a clinical …
Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy
Mitophagy facilitates the selective elimination of impaired or depolarized mitochondria
through targeting the latter to autophagosomes. Parkin becomes localized to depolarized …
through targeting the latter to autophagosomes. Parkin becomes localized to depolarized …
RBR E3 ubiquitin ligases: new structures, new insights, new questions
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double
RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain …
RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain …
Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies
Mutation of the gene PARK2, which encodes an E3 ubiquitin ligase, is the most common
cause of early-onset Parkinson's disease,,. In a search for multisite tumor suppressors, we …
cause of early-onset Parkinson's disease,,. In a search for multisite tumor suppressors, we …
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
S Geisler, KM Holmström, A Treis, D Skujat, SS Weber… - Autophagy, 2010 - Taylor & Francis
Mitochondrial dysfunction is an early sign of many neurodegenerative diseases. Very
recently, two Parkinson disease (PD) associated genes, PINK1 and Parkin, were shown to …
recently, two Parkinson disease (PD) associated genes, PINK1 and Parkin, were shown to …