[HTML][HTML] Towards the sustainable discovery and development of new antibiotics
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
Genetic platforms for heterologous expression of microbial natural products
Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …
Burkholderia as a Source of Natural Products
S Kunakom, AS Eustáquio - Journal of natural products, 2019 - ACS Publications
Burkholderia bacteria are multifaceted organisms that are ecologically and metabolically
diverse. The Burkholderia genus has gained prominence because it includes human …
diverse. The Burkholderia genus has gained prominence because it includes human …
Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria
Beneficial microorganisms are widely used in agriculture for control of plant pathogens, but
a lack of efficacy and safety information has limited the exploitation of multiple promising …
a lack of efficacy and safety information has limited the exploitation of multiple promising …
Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
K Tsukada, S Shinki, A Kaneko, K Murakami… - Nature …, 2020 - nature.com
A synthetic biology method based on heterologous biosynthesis coupled with genome
mining is a promising approach for increasing the opportunities to rationally access natural …
mining is a promising approach for increasing the opportunities to rationally access natural …
[HTML][HTML] A trait-based ecological perspective on the soil microbial antibiotic-related genetic machinery
Antibiotic resistance crisis dictates the need for resistance monitoring and the search for new
antibiotics. The development of monitoring protocols is hindered by the great diversity of …
antibiotics. The development of monitoring protocols is hindered by the great diversity of …
Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria
J Liu, H Zhou, Z Yang, X Wang, H Chen… - Nature …, 2021 - nature.com
Heterologous expression of biosynthetic gene clusters (BGCs) avails yield improvements
and mining of natural products, but it is limited by lacking of more efficient Gram-negative …
and mining of natural products, but it is limited by lacking of more efficient Gram-negative …
Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens
The emergence of multidrug-resistant bacteria poses a threat to global health and
necessitates the development of additional in vivo active antibiotics with diverse modes of …
necessitates the development of additional in vivo active antibiotics with diverse modes of …
Charting the lipopeptidome of nonpathogenic Pseudomonas
ABSTRACT A major source of pseudomonad-specialized metabolites is the nonribosomal
peptide synthetases (NRPSs) assembling siderophores and lipopeptides. Cyclic …
peptide synthetases (NRPSs) assembling siderophores and lipopeptides. Cyclic …
The confluence of big data and evolutionary genome mining for the discovery of natural products
This review covers literature between 2003–2021 The development and application of
genome mining tools has given rise to ever-growing genetic and chemical databases and …
genome mining tools has given rise to ever-growing genetic and chemical databases and …