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Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease
The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …
Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever
V Carloni, TV Luong, K Rombouts - Liver International, 2014 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third
leading cause of cancer death. Recent epidemiological data indicate that the mortality rate …
leading cause of cancer death. Recent epidemiological data indicate that the mortality rate …
SPARC: a potential target for functional nanomaterials and drugs
S Jiang, HF Sun, S Li, N Zhang, JS Chen… - Frontiers in Molecular …, 2023 - frontiersin.org
Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or BM-40, is a
matricellular protein which regulates cell adhesion, extracellular matrix production, growth …
matricellular protein which regulates cell adhesion, extracellular matrix production, growth …
SPARC in tumor pathophysiology and as a potential therapeutic target
Cell migration and metastasis greatly contribute to the progression of tumors. Secreted
Protein and Rich in Cysteine SPARC, as a multi-faceted protein, is highly expressed in …
Protein and Rich in Cysteine SPARC, as a multi-faceted protein, is highly expressed in …
SPARC overexpression promotes liver cancer cell proliferation and tumor growth
Z Gao, C Liu, L Yang, T He, X Wu, H Zhang… - Frontiers in molecular …, 2021 - frontiersin.org
Background: Secreted protein acidic and rich in cysteine (SPARC) plays an important role in
cancer development. The roles of SPARC in the liver hepatocellular carcinoma (LIHC) are …
cancer development. The roles of SPARC in the liver hepatocellular carcinoma (LIHC) are …
Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells
ZY Lin, WL Chuang - Biomedicine & Pharmacotherapy, 2012 - Elsevier
The common genes responsible for the characteristics of primary cultured invasive
phenotype hepatocellular carcinoma (HCC) cells were investigated. Primary cultured HCC …
phenotype hepatocellular carcinoma (HCC) cells were investigated. Primary cultured HCC …
The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease
Secreted protein acidic and rich in cysteine (SPARC) is an extracellular matrix glycoprotein
with pleiotropic functions, which is expressed in adipose, hepatic, muscular, and pancreatic …
with pleiotropic functions, which is expressed in adipose, hepatic, muscular, and pancreatic …
SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer
J Chen, M Wang, B ** anticancer ferric prodrugs based on the N-donor residues of human serum albumin carrier IIA subdomain
J Qi, Y Gou, Y Zhang, K Yang, S Chen… - Journal of Medicinal …, 2016 - ACS Publications
To improve the selectivity, delivery, and activity of ferric (Fe) anticancer agents, we design
prodrugs based on N-donor residues of the human serum albumin (HSA) carrier IIA …
prodrugs based on N-donor residues of the human serum albumin (HSA) carrier IIA …
SPARC inhibition accelerates NAFLD‐associated hepatocellular carcinoma development by dysregulating hepatic lipid metabolism
AM Onorato, E Fiore, J Bayo, C Casali… - Liver …, 2021 - Wiley Online Library
Background and aims Non‐alcoholic fatty liver (NAFLD) and its more serious form non‐
alcoholic steatohepatitis increase risk of hepatocellular carcinoma (HCC). Lipid metabolic …
alcoholic steatohepatitis increase risk of hepatocellular carcinoma (HCC). Lipid metabolic …