The gut microbiome as a modulator of healthy ageing

TS Ghosh, F Shanahan, PW O'Toole - … Reviews Gastroenterology & …, 2022 - nature.com
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …

The effects of polyphenols and other bioactives on human health

CG Fraga, KD Croft, DO Kennedy… - Food & function, 2019 - pubs.rsc.org
Although deficiencies in polyphenol intake do not result in specific deficiency diseases,
adequate intake of polyphenols could confer health benefits, especially with regard to …

Bioactivity of dietary polyphenols: The role of metabolites

SV Luca, I Macovei, A Bujor, A Miron… - Critical reviews in …, 2020 - Taylor & Francis
A polyphenol-rich diet protects against chronic pathologies by modulating numerous
physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation …

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

LY Zhao, JX Mei, G Yu, L Lei, WH Zhang… - … and Targeted Therapy, 2023 - nature.com
In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

A natural polyphenol exerts antitumor activity and circumvents anti–PD-1 resistance through effects on the gut microbiota

M Messaoudene, R Pidgeon, C Richard, M Ponce… - Cancer Discovery, 2022 - AACR
Several approaches to manipulate the gut microbiome for improving the activity of cancer
immune-checkpoint inhibitors (ICI) are currently under evaluation. Here, we show that oral …

[HTML][HTML] Gut microbiota modulation of efficacy and toxicity of cancer chemotherapy and immunotherapy

D Chrysostomou, LA Roberts, JR Marchesi, JM Kinross - Gastroenterology, 2023 - Elsevier
Accumulating evidence supports not only the functional role of the gut microbiome in cancer
development and progression but also its role in defining the efficacy and toxicity of …

Interaction of dietary polyphenols and gut microbiota: Microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health

G Catalkaya, K Venema, L Lucini, G Rocchetti… - Food …, 2020 - Wiley Online Library
The human gastrointestinal tract is inhabited by a vast number of microorganisms that are
called as the microbiota. Each individual harbors a unique gut microbial composition, this …

Where to look into the puzzle of polyphenols and health? The postbiotics and gut microbiota associated with human metabotypes

A Cortés‐Martín, MV Selma… - Molecular Nutrition & …, 2020 - Wiley Online Library
The full consensus on the role of dietary polyphenols as human‐health‐promoting
compounds remains elusive. The two‐way interaction between polyphenols and gut …

Dietary phenolic compounds: their health benefits and association with the gut microbiota

Y Matsumura, M Kitabatake, S Kayano, T Ito - Antioxidants, 2023 - mdpi.com
Oxidative stress causes various diseases, such as type II diabetes and dyslipidemia, while
antioxidants in foods may prevent a number of diseases and delay aging by exerting their …

Main drivers of (poly) phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?

CE Iglesias-Aguirre, A Cortés-Martín… - Food & function, 2021 - pubs.rsc.org
Despite the high human interindividual variability in response to (poly) phenol consumption,
the cause-and-effect relationship between some dietary (poly) phenols (flavanols and olive …