Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression
F Lüönd, S Tiede, G Christofori - British journal of cancer, 2021 - nature.com
Heterogeneity within a tumour increases its ability to adapt to constantly changing
constraints, but adversely affects a patient's prognosis, therapy response and clinical …
constraints, but adversely affects a patient's prognosis, therapy response and clinical …
Controversies around epithelial–mesenchymal plasticity in cancer metastasis
Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …
Distinct contributions of partial and full EMT to breast cancer malignancy
Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-
differentiation where cancer cells transit between various stages of an EMT continuum …
differentiation where cancer cells transit between various stages of an EMT continuum …
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
Emerging biological principles of metastasis
Metastases account for the great majority of cancer-associated deaths, yet this complex
process remains the least understood aspect of cancer biology. As the body of research …
process remains the least understood aspect of cancer biology. As the body of research …
Context-dependent EMT programs in cancer metastasis
Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary,
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …
Epithelial mesenchymal transition in tumor metastasis
Metastasis is the major cause of cancer-related deaths; therefore, the prevention and
treatment of metastasis are fundamental to improving clinical outcomes. Epithelial …
treatment of metastasis are fundamental to improving clinical outcomes. Epithelial …
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding
source of debate, largely owing to an inability to monitor transient and reversible EMT …
source of debate, largely owing to an inability to monitor transient and reversible EMT …
Epithelial–mesenchymal transition in tumor metastasis
KT Yeung, J Yang - Molecular oncology, 2017 - Wiley Online Library
The epithelial–mesenchymal transition (EMT) is a developmental program that enables
stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells …
stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells …
Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?
M Diepenbruck, G Christofori - Current opinion in cell biology, 2016 - Elsevier
An epithelial to mesenchymal transition (EMT) is a process of cell remodeling critical during
embryonic development and organogenesis. During an EMT, epithelial cells lose their …
embryonic development and organogenesis. During an EMT, epithelial cells lose their …