Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …

Multiple Myeloma (MM) is a hematological cancer characterized by proliferation of malignant
plasma cells in the bone marrow (BM). MM represents the second most frequent …

The P2X7 channel is involved in the pathogenesis of various CNS diseases. An increasing
number of studies suggest its presence in neurons where its putative functions remain …

For treatment and diagnosis of cancer, antibodies have proven their value and now serve as
a first line of therapy for certain cancers. A unique class of antibody fragments called …

Background Current measurements of multiple myeloma disease burden are suboptimal.
Daratumumab is a monoclonal antibody that targets CD38, an antigen expressed on nearly …

The development of monoclonal antibody treatments for successful tumor-targeted therapies
took several decades. However, the efficacy of antibody-based therapy is still confined and …

Chimeric antigen receptor (CAR) T therapy represents a form of immune cellular therapy
with clinical efficacy and a specific target. A typical chimeric antigen receptor (CAR) …

Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies
(Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their …

Therapeutics designed to target α-synuclein (α-syn) aggregation may be critical in halting
the progression of pathology in Parkinson's disease (PD) patients. Nanobodies are single …