In bacteria and archaea, clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …

CRISPR-Cas, the bacterial and archaeal adaptive immunity systems, encompass a complex
machinery that integrates fragments of foreign nucleic acids, mostly from mobile genetic …

Adaptive immunity of prokaryotes is mediated by CRISPR-Cas systems that employ a large
variety of Cas protein effectors to identify and destroy foreign genetic material. The different …

Many bacteria and archaea have the unique ability to heritably alter their genomes by
incorporating small fragments of foreign DNA, called spacers, into CRISPR loci. Once …

Prokaryotes have developed numerous defense strategies to combat the constant threat
posed by the diverse genetic parasites that endanger them. Clustered regularly interspaced …

Cross-linking mass spectrometry (XL-MS) has received considerable interest, owing to its
potential to investigate protein–protein interactions (PPIs) in an unbiased fashion in complex …

The ability to record transcriptional events within a cell over time would help to elucidate
how molecular events give rise to complex cellular behaviours and states. However, current …

Abstract The Clustered Regularly Interspaced Palindromic Repeats (CRISPR)-CRISPR-
associated proteins (Cas) systems of bacterial and archaeal adaptive immunity show …

Chemical cross-linking mass spectrometry is rapidly emerging as a prominent technique to
study protein structures. Structural information is obtained by covalently connecting peptides …

CRISPR-associated transposases (CASTs) direct DNA integration downstream of target
sites using the RNA-guided DNA binding activity of nuclease-deficient CRISPR-Cas …