Understanding flow chemistry for the production of active pharmaceutical ingredients

AS Burange, SM Osman, R Luque - Iscience, 2022 - cell.com
Multi-step organic syntheses of various drugs, active pharmaceutical ingredients, and other
pharmaceutically and agriculturally important compounds have already been reported using …

Impurity incorporation in solution crystallization: diagnosis, prevention, and control

G Capellades, JO Bonsu, AS Myerson - CrystEngComm, 2022 - pubs.rsc.org
Despite their widespread use for purification, our current methods for the development of
solution crystallization processes lack a sufficient understanding on how impurities …

PAT implementation on a mobile continuous pharmaceutical manufacturing system: real-time process monitoring with in-line FTIR and Raman spectroscopy

Y Miyai, A Formosa, C Armstrong… - … Process Research & …, 2021 - ACS Publications
The strategies and experimental methods for implementation of process analytical
technology (PAT) on the mobile pharmaceutical manufacturing system, Pharmacy on …

Towards antibiotic synthesis in continuous-flow processes

M Comito, R Monguzzi, S Tagliapietra, G Palmisano… - Molecules, 2023 - mdpi.com
Continuous-flow chemistry has become a mainstream process and a notable trend among
emerging technologies for drug synthesis. It is routinely used in academic and industrial …

On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Implementation and In Situ Control of Downstream Production

G Capellades, C Neurohr, N Briggs… - … Process Research & …, 2021 - ACS Publications
Traditional pharmaceutical manufacturing operates around a supply chain that is subject to
complex logistics and is vulnerable to spikes in demand and interruptions. In this context …

In silico screening and molecular docking study of quinoline based compounds with Human kallikrein 7 in complex with 1, 4-diazepane-7-one 1-acetamide derivative …

S Sharma, Y Monga, A Gupta… - Journal of Molecular …, 2023 - pubs.thesciencein.org
The quinolines based drugs and its analogues are widely used as a medicinal drug. In this
study, five compounds from quinoline-based pharmaceuticals have been discovered using …

Automated self-optimization of continuous crystallization of nirmatrelvir API

KY Nandiwale, RP Pritchard, CT Armstrong… - Reaction Chemistry & …, 2024 - pubs.rsc.org
Continuous flow crystallization is an attractive mode of operation, due to its ability to
generate consistent product quality while requiring a smaller footprint and lower production …

Impurity purging through systematic process development of a continuous two-stage crystallization

D Scott, NEB Briggs, A Formosa, A Burnett… - … Process Research & …, 2023 - ACS Publications
A methodical development approach was deployed in a novel portable manufacturing
(Pharmacy on Demand) unit to purify ciprofloxacin hydrochloride hydrate within assay, water …

Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing

DV Silva-Brenes, S Agrawal, V López-Mejías… - Reaction Chemistry & …, 2024 - pubs.rsc.org
This study reports efforts toward the integrated advanced manufacturing of the anti-
narcoleptic drug modafinil. It showcases a holistic approach from flow synthesis to …

Impurity retention and pharmaceutical solid solutions: visualizing the effect of impurities on dissolution and growth using dyed crystals

A Nong, C Schleper, A Martin, M Paolello… - …, 2024 - pubs.rsc.org
Pharmaceutical solid solutions are gaining increased interest as alternatives to salts and co-
crystals for the enhancement of drug solubility and dissolution kinetics. Industrially, they are …