Chemistries for DNA nanotechnology

M Madsen, KV Gothelf - Chemical reviews, 2019 - ACS Publications
The predictable nature of DNA interactions enables the programmable assembly of highly
advanced 2D and 3D DNA structures of nanoscale dimensions. The access to ever larger …

Recent advances in DNA origami-engineered nanomaterials and applications

P Zhan, A Peil, Q Jiang, D Wang, S Mousavi… - Chemical …, 2023 - ACS Publications
DNA nanotechnology is a unique field, where physics, chemistry, biology, mathematics,
engineering, and materials science can elegantly converge. Since the original proposal of …

Antibody–oligonucleotide conjugates as therapeutic, imaging, and detection agents

I Dovgan, O Koniev, S Kolodych… - Bioconjugate …, 2019 - ACS Publications
Antibody–oligonucleotide conjugates (AOCs) are a novel class of synthetic chimeric
biomolecules that has been continually gaining traction in different fields of modern …

Hybrid nanostructures from the self-assembly of proteins and DNA

N Stephanopoulos - Chem, 2020 - cell.com
Proteins and DNA are two commonly used molecules for self-assembling nanotechnology.
In this tutorial review, we discuss the hybrid field of" protein-DNA nanotechnology," whereby …

Advanced applications of DNA nanostructures dominated by DNA origami in antitumor drug delivery

Y Zhang, X Tian, Z Wang, H Wang, F Liu… - Frontiers in Molecular …, 2023 - frontiersin.org
DNA origami is a cutting-edge DNA self-assembly technique that neatly folds DNA strands
and creates specific structures based on the complementary base pairing principle. These …

Customized scaffolds for direct assembly of functionalized DNA origami

E Oktay, J Bush, M Vargas, DV Scarton… - … Applied Materials & …, 2023 - ACS Publications
Functional DNA origami nanoparticles (DNA-NPs) are used as nanocarriers in a variety of
biomedical applications including targeted drug delivery and vaccine development. DNA …

A functional RNA-origami as direct thrombin inhibitor with fast-acting and specific single-molecule reversal agents in vivo model

A Krissanaprasit, E Mihalko, K Meinhold, A Simpson… - Molecular Therapy, 2024 - cell.com
Injectable anticoagulants are widely used in medical procedures to prevent unwanted blood
clotting. However, many lack safe, effective reversal agents. Here, we present new data on a …

Multifunctional double-bundle DNA tetrahedron for efficient regulation of gene expression

T Wu, Q Liu, Y Cao, R Tian, J Liu… - ACS Applied Materials & …, 2020 - ACS Publications
DNA nanostructures have garnered considerable interest as research tools in the field of cell
biology and pathology. Herein, we develop an addressable double-bundle DNA tetrahedron …

Controllable covalent-bound nanoarchitectures from DNA frames

Z Lin, Y **ong, S **ang, O Gang - Journal of the American …, 2019 - ACS Publications
Could one manipulate nanoscale building blocks using chemical reactions like molecular
synthesis to yield new supra-nanoscale objects? The precise control over the final …

A computational mechanics model for producing molecular assembly using molecularly woven pantographs

B Goh, J Choi - Cell Reports Physical Science, 2024 - cell.com
The weave-based interlocking design has received considerable attention for preparing the
patterned linkage of molecules via formation and dissociation of highly non-covalent bonds …