[HTML][HTML] Mitochondrial impairment: A common motif in neuropsychiatric presentation? The link to the tryptophan–kynurenine metabolic system

M Tanaka, Á Szabó, E Spekker, H Polyák, F Tóth… - Cells, 2022 - mdpi.com
Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

[HTML][HTML] GSK-3 and tau: A key duet in Alzheimer's disease

CL Sayas, J Ávila - Cells, 2021 - mdpi.com
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
with a plethora of substrates. As a modulator of several cellular processes, GSK-3 has a …

Organic cation transporters in health and disease

H Koepsell - Pharmacological reviews, 2020 - Elsevier
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases

E Beurel, SF Grieco, RS Jope - Pharmacology & therapeutics, 2015 - Elsevier
Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

The physiology, signaling, and pharmacology of dopamine receptors

JM Beaulieu, RR Gainetdinov - Pharmacological reviews, 2011 - Elsevier
G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …

Targeting PI3K-AKT/mTOR signaling in the prevention of autism

A Sharma, S Mehan - Neurochemistry International, 2021 - Elsevier
Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …

Glycogen synthase kinase-3 inhibitors: preclinical and clinical focus on CNS-A decade onward

SM Arciniegas Ruiz, H Eldar-Finkelman - Frontiers in molecular …, 2022 - frontiersin.org
The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

GSK3 signalling in neural development

EM Hur, FQ Zhou - Nature Reviews Neuroscience, 2010 - nature.com
Recent evidence suggests that glycogen synthase kinase 3 (GSK3) proteins and their
upstream and downstream regulators have key roles in many fundamental processes during …

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

RS Duman, B Voleti - Trends in neurosciences, 2012 - cell.com
Basic and clinical studies demonstrate that stress and depression are associated with
atrophy and loss of neurons and glia, which contribute to the decreased size and function of …

GSK-3: functional insights from cell biology and animal models

O Kaidanovich-Beilin, JR Woodgett - Frontiers in molecular …, 2011 - frontiersin.org
Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved
serine/threonine protein kinase encoded in mammals by two genes that generate two …