Metabolic syndrome: updates on pathophysiology and management in 2021

G Fahed, L Aoun, M Bou Zerdan, S Allam… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …

Lipid droplet biogenesis and functions in health and disease

A Zadoorian, X Du, H Yang - Nature Reviews Endocrinology, 2023 - nature.com
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

The role of hepatokines in NAFLD

N Stefan, F Schick, AL Birkenfeld, HU Häring, MF White - Cell metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …

Adipokines, hepatokines and myokines: focus on their role and molecular mechanisms in adipose tissue inflammation

Y Ren, H Zhao, C Yin, X Lan, L Wu, X Du… - Frontiers in …, 2022 - frontiersin.org
Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

D Pal, S Dasgupta, R Kundu, S Maitra, G Das… - Nature medicine, 2012 - nature.com
Abstract Toll-like receptor 4 (TLR4) has a key role in innate immunity by activating an
inflammatory signaling pathway. Free fatty acids (FFAs) stimulate adipose tissue …

Inflammation and lipid signaling in the etiology of insulin resistance

CK Glass, JM Olefsky - Cell metabolism, 2012 - cell.com
Inflammation and lipid signaling are intertwined modulators of homeostasis and immunity. In
addition to the extensively studied eicosanoids and inositol phospholipids, emerging studies …

Metabolic implications of pancreatic fat accumulation

R Wagner, SS Eckstein, H Yamazaki, F Gerst… - Nature Reviews …, 2022 - nature.com
Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on
systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received …

The role of exercise in the interplay between myokines, hepatokines, osteokines, adipokines, and modulation of inflammation for energy substrate redistribution and …

AM Gonzalez-Gil, L Elizondo-Montemayor - Nutrients, 2020 - mdpi.com
Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

[HTML][HTML] Hepatokines and metabolism: Deciphering communication from the liver

SO Jensen-Cody, MJ Potthoff - Molecular metabolism, 2021 - Elsevier
Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …

The role of hepatokines in metabolism

N Stefan, HU Häring - Nature Reviews Endocrinology, 2013 - nature.com
The liver is known to be involved in the natural history of the ongoing epidemics of type 2
diabetes mellitus and cardiovascular disease. In particular, the liver has a role in increased …