Metabolic syndrome: updates on pathophysiology and management in 2021
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …
Lipid droplet biogenesis and functions in health and disease
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
The role of hepatokines in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …
but it is also an important cause of insulin resistance and major non-communicable diseases …
Adipokines, hepatokines and myokines: focus on their role and molecular mechanisms in adipose tissue inflammation
Y Ren, H Zhao, C Yin, X Lan, L Wu, X Du… - Frontiers in …, 2022 - frontiersin.org
Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Abstract Toll-like receptor 4 (TLR4) has a key role in innate immunity by activating an
inflammatory signaling pathway. Free fatty acids (FFAs) stimulate adipose tissue …
inflammatory signaling pathway. Free fatty acids (FFAs) stimulate adipose tissue …
Inflammation and lipid signaling in the etiology of insulin resistance
Inflammation and lipid signaling are intertwined modulators of homeostasis and immunity. In
addition to the extensively studied eicosanoids and inositol phospholipids, emerging studies …
addition to the extensively studied eicosanoids and inositol phospholipids, emerging studies …
Metabolic implications of pancreatic fat accumulation
Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on
systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received …
systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received …
The role of exercise in the interplay between myokines, hepatokines, osteokines, adipokines, and modulation of inflammation for energy substrate redistribution and …
Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …
[HTML][HTML] Hepatokines and metabolism: Deciphering communication from the liver
SO Jensen-Cody, MJ Potthoff - Molecular metabolism, 2021 - Elsevier
Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
The role of hepatokines in metabolism
The liver is known to be involved in the natural history of the ongoing epidemics of type 2
diabetes mellitus and cardiovascular disease. In particular, the liver has a role in increased …
diabetes mellitus and cardiovascular disease. In particular, the liver has a role in increased …