The paper outlines a 2-tier approach for wide-scale biomonitoring programmes. To obtain a
high level of standardization, we suggest the use of caged organisms (mussels or fish). An …

Toxicogenomics combines transcript, protein and metabolite profiling with conventional
toxicology to investigate the interaction between genes and environmental stress in disease …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

The early and high-throughput application of assays for non-genetic toxicity is of great
interest to the pharmaceutical industry, although few systems have been validated as being …

There is increasing interest in the use of quantitative transcriptomic data to determine
benchmark dose (BMD) and estimate a point of departure (POD) for human health risk …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …

The application of gene expression profiling technology to examine multiple genes and
signaling pathways simultaneously promises a significant advance in understanding toxic …

Toxicology can no longer be used only as a science that reacts to problems but must be
more proactive in predicting potential human safety issues with new drug candidates …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …