Structure, function, and pharmacology of glutamate receptor ion channels

KB Hansen, LP Wollmuth, D Bowie, H Furukawa… - Pharmacological …, 2021 - Elsevier
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Autoantibodies in neurological disease

H Prüss - Nature reviews immunology, 2021 - nature.com
The realization that autoantibodies can contribute to dysfunction of the brain has brought
about a paradigm shift in neurological diseases over the past decade, offering up important …

Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system

J Dalmau, C Geis, F Graus - Physiological reviews, 2017 - journals.physiology.org
Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …

Seronegative autoimmune diseases: A challenging diagnosis

MV Lenti, CM Rossi, F Melazzini, M Gastaldi… - Autoimmunity …, 2022 - Elsevier
Autoimmune diseases (AID) are increasingly prevalent conditions which comprise more
than 100 distinct clinical entities that are responsible for a great disease burden worldwide …

The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis

A Van Sonderen, M Petit-Pedrol, J Dalmau… - Nature Reviews …, 2017 - nature.com
The discovery, in 2010, of autoantibodies against the extracellular proteins LGI1 and Caspr2
facilitated a change of view regarding the clinical importance of voltage-gated potassium …

Cerebrospinal fluid findings in patients with autoimmune encephalitis—a systematic analysis

T Blinder, J Lewerenz - Frontiers in neurology, 2019 - frontiersin.org
Autoimmune encephalitides (AIE) comprise a group of inflammatory diseases of the central
nervous system (CNS), which can be further characterized by the presence of different …

Autoimmune seizures and epilepsy

C Geis, J Planagumà, M Carreño, F Graus… - The Journal of clinical …, 2019 - jci.org
The rapid expansion in the number of encephalitis disorders associated with autoantibodies
against neuronal proteins has led to an incremental increase in use of the term “autoimmune …

Encephalitis and AMPA receptor antibodies: novel findings in a case series of 22 patients

R Höftberger, A van Sonderen, F Leypoldt, D Houghton… - Neurology, 2015 - neurology.org
Objective: We report the clinical features, comorbidities, and outcome of 22 newly identified
patients with antibodies to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid …

NMDA receptor encephalitis and other antibody-mediated disorders of the synapse: The 2016 Cotzias Lecture

J Dalmau - Neurology, 2016 - neurology.org
Investigations during the last 10 years have revealed a group of disorders mediated by
antibodies against ion channels and synaptic receptors, which cause both neurologic and …

The next generation of approaches to investigate the link between synaptic plasticity and learning

Y Humeau, D Choquet - Nature neuroscience, 2019 - nature.com
Activity-dependent synaptic plasticity has since long been proposed to represent the
subcellular substrate of learning and memory, one of the most important behavioral …