Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

CRISPR-Cas9 genome editing technology holds great promise for discovering therapeutic
targets in cancer and other diseases. Current screening strategies target CRISPR-Cas9 …

Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their …

Standard induction chemotherapy, consisting of an anthracycline and cytarabine, has been
the first-line therapy for many years to treat acute myeloid leukemia (AML). Although this …

Mammalian embryonic development is a tightly regulated process that, from a single zygote,
produces a large number of cell types with hugely divergent functions. Distinct cellular …

Post-translational modifications of DNA and histones are epigenetic mechanisms, which
affect the chromatin structure, ultimately leading to gene expression changes. A number of …

Mutations in the isocitrate dehydrogenase-1 gene (IDH1) are common drivers of acute
myeloid leukemia (AML) but their mechanism is not fully understood. It is thought that IDH1 …

Histone deacetylases (HDACs) are a class of enzymes that remove acetyl from the ε-N-
acetyl lysine of histones, allowing histones to wrap DNA more tightly. HDACs play an …

Metastasis, therapy failure and tumour recurrence are major clinical challenges in cancer.
The interplay between tumour‐initiating cells (TICs) and epithelial–mesenchymal transition …