The vascular system forms as a branching network of endothelial cells that acquire identity
as arterial, venous, hemogenic, or lymphatic. Endothelial specification depends on gene …

Cytosolic DNA acts as a universal danger-associated molecular pattern (DAMP) signal;
however, the mechanisms of self-DNA release into the cytosol and its role in inflammatory …

Extensive efforts have been made to achieve vascular regeneration accompanying tissue
repair for treating vascular dysfunction-associated diseases. Recent advancements in stem …

Repair of the endothelial cell barrier after inflammatory injury is essential for tissue fluid
homeostasis and normalizing leukocyte transmigration. However, the mechanisms of …

Rationale: Direct conversion or reprogramming of human postnatal cells into endothelial
cells (ECs), bypassing stem or progenitor cell status, is crucial for regenerative medicine …

The cross-talk between angiogenesis and immunity within the tumor microenvironment
(TME) is critical for tumor prognosis. While pro-angiogenic and immunosuppressive TME …

The 'master regulatory factors' that position at the top of the genetic hierarchy of lineage
determination have been a focus of intense interest, and have been investigated in various …

Morphological change in endothelial cells is an initial and crucial step in the process of
establishing a functional vascular network. Following or associated with differentiation and …

Background: Sepsis is a major cause of ICU admissions, with high mortality and morbidity.
The lungs are particularly vulnerable to infection and injury, and restoration of vascular …

The development and function of stem and progenitor cells that produce blood cells are vital
in physiology. GATA-binding protein 2 (GATA2) mutations cause GATA-2 deficiency …