Type I interferon in the pathogenesis of lupus
MK Crow - The Journal of Immunology, 2014 - journals.aai.org
Investigations of patients with systemic lupus erythematosus have applied insights from
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …
studies of the innate immune response to define IFN-I, with IFN-α as the dominant mediator …
The activation of bystander CD8+ T cells and their roles in viral infection
During viral infections, significant numbers of T cells are activated in a T cell receptor-
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …
HIV-1 and interferons: who's interfering with whom?
T Doyle, C Goujon, MH Malim - Nature Reviews Microbiology, 2015 - nature.com
The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long
been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who …
been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who …
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption
Type 1 interferons (IFN-I) are potent innate antiviral effectors that constrain HIV-1
transmission. However, harnessing these cytokines for HIV-1 cure strategies has been …
transmission. However, harnessing these cytokines for HIV-1 cure strategies has been …
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV
M OhAinle, L Helms, J Vermeire, F Roesch, D Humes… - Elife, 2018 - elifesciences.org
Interferon (IFN) inhibits HIV replication by inducing antiviral effectors. To comprehensively
identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of …
identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of …
Human dendritic cell subsets, ontogeny, and impact on HIV infection
JW Rhodes, O Tong, AN Harman… - Frontiers in …, 2019 - frontiersin.org
Dendritic cells (DCs) play important roles in orchestrating host immunity against invading
pathogens, representing one of the first responders to infection by mucosal invaders. From …
pathogens, representing one of the first responders to infection by mucosal invaders. From …
[HTML][HTML] Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs
Chronic immune activation, immunosuppression, and T cell exhaustion are hallmarks of HIV
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …
infection, yet the mechanisms driving these processes are unclear. Chronic activation can …
Interferon lambda genetics and biology in regulation of viral control
Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition
to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce …
to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce …
Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection
Although type I interferon (IFN-I) is thought to be beneficial against microbial infections,
persistent viral infections are characterized by high interferon signatures suggesting that IFN …
persistent viral infections are characterized by high interferon signatures suggesting that IFN …
[BOOK][B] Nutraceuticals in veterinary medicine
RC Gupta, A Srivastava, R Lall - 2019 - Springer
According to the North American Veterinary Nutraceutical Council, a veterinary nutraceutical
is defined as “a substance which is produced in a purified or extracted form and …
is defined as “a substance which is produced in a purified or extracted form and …