[HTML][HTML] The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases
X Shi, H Zhou, J Wei, W Mo, Q Li, X Lv - Redox biology, 2022 - Elsevier
Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …
Biomass-derived production of itaconic acid as a building block in specialty polymers
Biomass, the only source of renewable organic carbon on Earth, offers an efficient substrate
for bio-based organic acid production as an alternative to the leading petrochemical industry …
for bio-based organic acid production as an alternative to the leading petrochemical industry …
Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury
Objectives Cerebral ischemia/reperfusion (IR) drives oxidative stress and injurious
metabolic processes that lead to redox imbalance, inflammation, and tissue damage …
metabolic processes that lead to redox imbalance, inflammation, and tissue damage …
Itaconate controls the severity of pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease in which airway macrophages
(AMs) play a key role. Itaconate has emerged as a mediator of macrophage function, but its …
(AMs) play a key role. Itaconate has emerged as a mediator of macrophage function, but its …
Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis
T Frangos, W Maret - Nutrients, 2020 - mdpi.com
Osteoarthritis (OA) and rheumatoid arthritis (RA) are inflammatory articular conditions with
different aetiology, but both result in joint damage. The nutritionally essential metal zinc …
different aetiology, but both result in joint damage. The nutritionally essential metal zinc …
The metabolic basis of immune dysfunction following sepsis and trauma
MA McBride, AM Owen, CL Stothers… - Frontiers in …, 2020 - frontiersin.org
Critically ill, severely injured and high-risk surgical patients are vulnerable to secondary
infections during hospitalization and after hospital discharge. Studies show that the …
infections during hospitalization and after hospital discharge. Studies show that the …
[HTML][HTML] Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose
J Muri, H Wolleb, P Broz, EM Carreira, M Kopf - Redox Biology, 2020 - Elsevier
Controlling inflammation is critical for preventing many diseases including cancer,
autoimmune disorders and hypersensitivity reactions. NF-E2-related factor 2 (Nrf2) is a key …
autoimmune disorders and hypersensitivity reactions. NF-E2-related factor 2 (Nrf2) is a key …
Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1
Abstract cis-Aconitate decarboxylase (ACOD1, IRG1) converts cis-aconitate to the
immunomodulatory and antibacterial metabolite itaconate. Although the active site residues …
immunomodulatory and antibacterial metabolite itaconate. Although the active site residues …
Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection
The eye is highly susceptible to inflammation-mediated tissue damage evoked during
bacterial infection. However, mechanisms regulating inflammation to protect the eye remain …
bacterial infection. However, mechanisms regulating inflammation to protect the eye remain …
Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ
Microglia are tissue resident macrophages (innate immunity) and universal sensors of
alterations in CNS physiology. In response to pathogen or damage signals, microglia feature …
alterations in CNS physiology. In response to pathogen or damage signals, microglia feature …