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T cell responses to SARS-CoV-2
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …
Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases
S Wang, B Liang, W Wang, L Li, N Feng… - Signal transduction and …, 2023 - nature.com
Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …
challenges to public health security and the global economy. The development and …
Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
Vaccines play a critical role in combating the COVID-19 pandemic. Future control of the
pandemic requires improved vaccines with high efficacy against newly emerging SARS-CoV …
pandemic requires improved vaccines with high efficacy against newly emerging SARS-CoV …
Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology
Evidence suggests that innate and adaptive cellular responses mediate resistance to the
influenza virus and confer protection after vaccination. However, few studies have resolved …
influenza virus and confer protection after vaccination. However, few studies have resolved …
Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters
L Zhang, Y Jiang, J He, J Chen, R Qi, L Yuan… - Nature …, 2023 - nature.com
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
and “anatomical escape” characteristics threaten the effectiveness of current coronavirus …
and “anatomical escape” characteristics threaten the effectiveness of current coronavirus …
An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters
S Deng, Y Liu, RCY Tam, P Chen, AJ Zhang… - Nature …, 2023 - nature.com
Current available vaccines for COVID-19 are effective in reducing severe diseases and
deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. Next …
deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. Next …
Prevention of respiratory virus transmission by resident memory CD8+ T cells
An ideal vaccine both attenuates virus growth and disease in infected individuals and
reduces the spread of infections in the population, thereby generating herd immunity …
reduces the spread of infections in the population, thereby generating herd immunity …
[HTML][HTML] Next generation mucosal vaccine strategy for respiratory pathogens
F Dotiwala, AK Upadhyay - Vaccines, 2023 - mdpi.com
Inducing humoral and cytotoxic mucosal immunity at the sites of pathogen entry has the
potential to prevent the infection from getting established. This is different from systemic …
potential to prevent the infection from getting established. This is different from systemic …
[HTML][HTML] Status and challenges for vaccination against avian H9N2 influenza virus in China
J Dong, Y Zhou, J Pu, L Liu - Life, 2022 - mdpi.com
In China, H9N2 avian influenza virus (AIV) has become widely prevalent in poultry, causing
huge economic losses after secondary infection with other pathogens. Importantly, H9N2 …
huge economic losses after secondary infection with other pathogens. Importantly, H9N2 …
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19
The relationship between diabetes and coronavirus disease 2019 (COVID-19) is
bidirectional: Although individuals with diabetes and high blood glucose (hyperglycemia) …
bidirectional: Although individuals with diabetes and high blood glucose (hyperglycemia) …