T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases

S Wang, B Liang, W Wang, L Li, N Feng… - Signal transduction and …, 2023 - nature.com
Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters

G Nouailles, JM Adler, P Pennitz, S Peidli… - Nature …, 2023 - nature.com
Vaccines play a critical role in combating the COVID-19 pandemic. Future control of the
pandemic requires improved vaccines with high efficacy against newly emerging SARS-CoV …

Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology

RC Mettelman, A Souquette, LA Van de Velde… - Nature …, 2023 - nature.com
Evidence suggests that innate and adaptive cellular responses mediate resistance to the
influenza virus and confer protection after vaccination. However, few studies have resolved …

Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters

L Zhang, Y Jiang, J He, J Chen, R Qi, L Yuan… - Nature …, 2023 - nature.com
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
and “anatomical escape” characteristics threaten the effectiveness of current coronavirus …

An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters

S Deng, Y Liu, RCY Tam, P Chen, AJ Zhang… - Nature …, 2023 - nature.com
Current available vaccines for COVID-19 are effective in reducing severe diseases and
deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. Next …

Prevention of respiratory virus transmission by resident memory CD8+ T cells

I Uddbäck, SE Michalets, A Saha, C Mattingly, KN Kost… - Nature, 2024 - nature.com
An ideal vaccine both attenuates virus growth and disease in infected individuals and
reduces the spread of infections in the population, thereby generating herd immunity …

[HTML][HTML] Next generation mucosal vaccine strategy for respiratory pathogens

F Dotiwala, AK Upadhyay - Vaccines, 2023 - mdpi.com
Inducing humoral and cytotoxic mucosal immunity at the sites of pathogen entry has the
potential to prevent the infection from getting established. This is different from systemic …

[HTML][HTML] Status and challenges for vaccination against avian H9N2 influenza virus in China

J Dong, Y Zhou, J Pu, L Liu - Life, 2022 - mdpi.com
In China, H9N2 avian influenza virus (AIV) has become widely prevalent in poultry, causing
huge economic losses after secondary infection with other pathogens. Importantly, H9N2 …

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19

B Zhu, X Wei, H Narasimhan, W Qian, R Zhang… - Science …, 2023 - science.org
The relationship between diabetes and coronavirus disease 2019 (COVID-19) is
bidirectional: Although individuals with diabetes and high blood glucose (hyperglycemia) …