B-cell receptor (BCR) is a B cell hallmark surface complex regulating multiple cellular
processes in normal as well as malignant B cells. Igα (CD79a)/Igβ (CD79b) are essential …

The B cell receptor (BCR) pathway has been identified as a potential therapeutic target in a
number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse …

Concerns that airborne microplastics (MP) may be detrimental to human health are rising.
However, research on the effects of MP on the respiratory system are limited. We tested the …

The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain
glycans (VDGs). Their abundant occurrence results from the selective introduction of N …

CD20 is a B cell-specific membrane protein and represents an attractive target for
therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies for B cell …

Objective Autoantibodies against antigens carrying distinct post-translational modifications
(PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of rheumatoid …

The BCR consists of surface-bound Ig and a heterodimeric signaling unit comprised of
CD79A and CD79B. Upon cognate Ag recognition, the receptor initiates important signals …

The immune system is strictly regulated by glycosylation through the addition of highly
diverse and dynamically changing sugar structures (glycans) to the majority of immune cell …

Cancer has always been a threat to human health with its high morbidity and mortality rates.
Traditional therapy, including surgery, chemotherapy and radiotherapy, plays a key role in …

CD38 is a multifunctional protein expressed on the surface of B cells in healthy individuals
but also in B cell malignancies. Previous studies have suggested a connection between …