In this Review, we describe the singular success of attractor neural network models in
describing how the brain maintains persistent activity states for working memory, corrects …

The neocortex is a complex neurobiological system with many interacting regions. How
these regions work together to subserve flexible behavior and cognition has become …

The neural circuits responsible for animal behavior remain largely unknown. We summarize
new methods and present the circuitry of a large fraction of the brain of the fruit fly …

To understand the brain we must relate neurons' functional responses to the circuit
architecture that shapes them. Here, we present a large functional connectomics dataset …

Due to advances in automated image acquisition and analysis, whole-brain connectomes
with 100,000 or more neurons are on the horizon. Proofreading of whole-brain automated …

Understanding cellular architecture is essential for understanding biology. Electron
microscopy (EM) uniquely visualizes cellular structures with nanometre resolution. However …

High-resolution electron microscopy of nervous systems has enabled the reconstruction of
synaptic connectomes. However, we do not know the synaptic sign for each connection (ie …

Changes in the microbiota are associated with alterations in nervous system structure-
function and behavior and have been implicated in the etiology of neuropsychiatric and …

Due to advances in electron microscopy and deep learning, it is now practical to reconstruct
a connectome, a description of neurons and the chemical synapses between them, for …

Principles of Neurobiology, Second Edition presents the major concepts of neuroscience
with an emphasis on how we know what we know. The text is organized around a series of …