Quinoline hybrids and their antiplasmodial and antimalarial activities
YQ Hu, C Gao, S Zhang, L Xu, Z Xu, LS Feng… - European Journal of …, 2017 - Elsevier
Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …
parasite species, responsible for nearly one million deaths every year), is one of the most …
Isatin and its derivatives: a survey of recent syntheses, reactions, and applications
R Kakkar - MedChemComm, 2019 - pubs.rsc.org
Isatin (1H-indole-2, 3-dione) and its derivatives represent an important class of heterocyclic
compounds that can be used as precursors for drug synthesis. Since its discovery, a lot of …
compounds that can be used as precursors for drug synthesis. Since its discovery, a lot of …
Isatin derivatives and their anti-bacterial activities
H Guo - European Journal of Medicinal Chemistry, 2019 - Elsevier
Bacterial infections are account for the majority of hospital-acquired and community-
acquired infections. The emergency and widespread of drug-resistant pathogens has further …
acquired infections. The emergency and widespread of drug-resistant pathogens has further …
Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-Schiff bases of isatin and their derivatives
Twelve new bis-Schiff bases of isatin, benzylisatin and 5-fluoroisatin 3a-3l were prepared by
condensation of isatin, benzylisatin and 5-fluoroisatin with primary aromatic amines. The …
condensation of isatin, benzylisatin and 5-fluoroisatin with primary aromatic amines. The …
Next‐generation antimalarial drugs: hybrid molecules as a new strategy in drug design
FW Muregi, A Ishih - Drug development research, 2010 - Wiley Online Library
Malaria is a disease that affects nearly 40% of the global population, and chemotherapy
remains the mainstay of its control strategy. The global malaria situation is increasingly …
remains the mainstay of its control strategy. The global malaria situation is increasingly …
Isatin derivatives as broad-spectrum antiviral agents: the current landscape
In recent decades, several viruses have resulted in large outbreaks with serious health,
economic and social consequences. The current unprecedented outbreak of the new …
economic and social consequences. The current unprecedented outbreak of the new …
Comprehensive review on various strategies for antimalarial drug discovery
M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …
limiting our ability to manage this severe disease and finally lead to a massive global health …
Ferroquine and its derivatives: new generation of antimalarial agents
Malaria has been teasing human populations from a long time. Presently, several classes of
antimalarial drugs are available in market, but the issues of toxicity, lower efficacy and the …
antimalarial drugs are available in market, but the issues of toxicity, lower efficacy and the …
Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease
SARS-CoV-2 pandemic in the end of 2019 led to profound consequences on global health
and economy. Till producing successful vaccination strategies, the healthcare sectors …
and economy. Till producing successful vaccination strategies, the healthcare sectors …
Synthesis and in vitro antitubercular activity of a series of quinoline derivatives
MVN De Souza, KC Pais, CR Kaiser, MA Peralta… - Bioorganic & medicinal …, 2009 - Elsevier
A series of 33 quinoline derivatives have been synthesized and evaluated for their in vitro
antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar Blue …
antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar Blue …