1, 3, 4-thiadiazole: A privileged scaffold for drug design and development

X Han, YL Yu, YS Hu, XH Liu - Current Topics in Medicinal …, 2021 - benthamdirect.com
1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …

Heterocycle compounds with antimicrobial activity

M Fesatidou, A Petrou, G Athina - Current pharmaceutical …, 2020 - ingentaconnect.com
Background: Bacterial infections are a growing problem worldwide causing morbidity and
mortality mainly in develo** countries. Moreover, the increased number of …

Novel flavonol derivatives containing 1, 3, 4-thiadiazole as potential antifungal agents: design, synthesis, and biological evaluation

Y Zhou, C Gong, Z Sun, W Zeng, K Meng, Y An… - ACS …, 2024 - ACS Publications
In order to discover novel compounds with excellent agricultural activities, novel flavonol
derivatives containing 1, 3, 4-thiadiazole were synthesized and evaluated for their antifungal …

Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors

B Kurban, BN Sağlık, D Osmaniye, S Levent… - ACS …, 2023 - ACS Publications
Lung cancer is one of the most common cancer types of cancer with the highest mortality
rates. However, while epidermal growth factor receptor (EGFR) is an important parameter for …

Development of a chitosan derivative bearing the thiadiazole moiety and evaluation of its antifungal and larvicidal efficacy

AG Ibrahim, WE Elgammal, AH Hashem, AE Mohamed… - Polymer Bulletin, 2024 - Springer
A new chitosan derivative bearing a new thiadiazole compound was developed, and its
antifungal and larvicidal activities were investigated. The chitosan derivative (coded here as …

New N-(1,3,4-thiadiazole-2-yl)acetamide derivatives as human carbonic anhydrase I and II and acetylcholinesterase inhibitors

S Dawbaa, C Türkeş, D Nuha, Y Demir… - Journal of …, 2024 - Taylor & Francis
Various carbonic anhydrase (CA) enzyme isoforms are known today. In addition to the use
of CA inhibitors as diuretics, antiepileptics and antiglaucoma agents, the inhibition of other …

Synthesis, biological evaluation, and molecular modeling studies of new 1, 3, 4‐thiadiazole derivatives as potent antimicrobial agents

U Acar Çevik, I Celik, U İnce, Z Maryam… - Chemistry & …, 2023 - Wiley Online Library
In this work, the synthesis, characterization, and biological activities of a new series of 1, 3, 4‐
thiadiazole derivatives were investigated. The structures of final compounds were identified …

Synthesis, molecular docking, dynamics, quantum-chemical computation, and antimicrobial activity studies of some new benzimidazole–thiadiazole hybrids

I Celik, UA Çevik, A Karayel, A Işık, U Kayış… - ACS …, 2022 - ACS Publications
In this study, some new compounds, which are 2-aminothiadiazole derivatives linked by a
phenyl bridge to the 2-position of the benzimidazole ring, were designed and synthesized as …

SAR analysis of heterocyclic compounds with monocyclic and bicyclic structures as antifungal agents

L Yang, W Bo Xu, L Sun, C Zhang… - ChemMedChem, 2022 - Wiley Online Library
Infections caused by eukaryotic organisms, such as fungi, are generally more difficult to treat
than bacterial infections. With the widespread use of antifungal drugs in humans and plants …

[HTML][HTML] 1, 3, 4-Thiadiazole-containing azo dyes: Synthesis, spectroscopic properties and molecular structure

A Kudelko, M Olesiejuk, M Luczynski, M Swiatkowski… - Molecules, 2020 - mdpi.com
Three series of azo dyes derived from 2-amino-5-aryl-1, 3, 4-thiadiazoles and aniline, N, N-
dimethylaniline and phenol were synthesized in high yields by a conventional diazotization …