Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles

G Bordanaba-Florit, F Royo, SG Kruglik… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs) are heterogeneous lipid containers with a complex molecular
cargo comprising several populations with unique roles in biological processes. These …

Advances of surface-enhanced Raman spectroscopy in exosomal biomarkers analysis

HS Tan, T Wang, HN Sun, A Liu, SS Li - TrAC Trends in Analytical …, 2023 - Elsevier
Cancer derived exosomal biomarkers (eg proteins, RNAs) could reflect important
information about the cancer microenvironment. For ultrasensitive analysis of exosomal …

Integrated microfluidic-SERS for exosome biomarker profiling and osteosarcoma diagnosis

Z Han, X Peng, Y Yang, J Yi, D Zhao, Q Bao… - Biosensors and …, 2022 - Elsevier
Osteosarcoma is one of the most frequent primary sarcoma of bone among adolescents.
Early diagnosis of osteosarcoma is the key factor to achieve high survival rate of patients …

Microfluidic Raman biochip detection of exosomes: a promising tool for prostate cancer diagnosis

Y Wang, Q Li, H Shi, K Tang, L Qiao, G Yu, C Ding… - Lab on a Chip, 2020 - pubs.rsc.org
Tumor-derived exosomes, which contain RNA, DNA, and proteins, are a potentially rich non-
invasive source of biomarkers. However, no efficient isolation or detection methods are yet …

Ultrasensitive single extracellular vesicle detection using high throughput droplet digital enzyme-linked immunosorbent assay

Z Yang, Y Atiyas, H Shen, MJ Siedlik, J Wu, K Beard… - Nano …, 2022 - ACS Publications
Extracellular vesicles (EVs) have attracted enormous attention for their diagnostic and
therapeutic potential. However, it has proven challenging to achieve the sensitivity to detect …

A holistic review of the state‐of‐the‐art microfluidics for exosome separation: an overview of the current status, existing obstacles, and future outlook

L Ding, X Yang, Z Gao, CY Effah, X Zhang, Y Wu, L Qu - Small, 2021 - Wiley Online Library
Exosomes, a class of small extracellular vesicles (30–150 nm), are secreted by almost all
types of cells into virtually all body fluids. These small vesicles are attracting increasing …

[HTML][HTML] Tumor circulome in the liquid biopsies for cancer diagnosis and prognosis

J Wu, S Hu, L Zhang, J **n, C Sun, L Wang, K Ding… - Theranostics, 2020 - ncbi.nlm.nih.gov
Liquid biopsy is a convenient, fast, non-invasive and reproducible sampling method that can
dynamically reflect the changes in tumor gene expression profile, and provide a robust basis …

Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer

CM Abreu, B Costa-Silva, RL Reis, SC Kundu… - Lab on a Chip, 2022 - pubs.rsc.org
Extracellular vesicles (EVs) are small lipidic particles packed with proteins, DNA, messenger
RNA and microRNAs of their cell of origin that act as critical players in cell–cell …

Perspectives of microscopy methods for morphology characterisation of extracellular vesicles from human biofluids

M Malenica, M Vukomanović, M Kurtjak, V Masciotti… - Biomedicines, 2021 - mdpi.com
Extracellular vesicles (EVs) are nanometric membranous structures secreted from almost
every cell and present in biofluids. Because EV composition reflects the state of its parental …

Surface functionalization strategies of extracellular vesicles

S Rayamajhi, S Aryal - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Extracellular vesicles (EVs) are lipid–protein bilayer vesicular constructs secreted to the
extracellular spaces by cells. All cells secrete EVs as a regular biological process that …