Mitochondria are the powerhouse of the cell and dynamically control fundamental biological
processes including cell reprogramming, pluripotency, and lineage specification. Although …

Type 1 Diabetes (T1D) is an autoimmune destruction of pancreatic beta cells. The
development of the Edmonton Protocol for islet transplantation in 2000 revolutionized T1D …

Background Human pluripotent stem cells (hPSCs) have an enormous therapeutic potential,
but large quantities of cells will need to be supplied by reliable, economically viable …

Extracellular vesicles (EVs) secreted by human‐induced pluripotent stem cells (hiPSCs)
have great potential as cell‐free therapies in various diseases, including prevention of blood …

Background. Induced pluripotent stem cells (iPSCs) offer the potential to generate
autologous iPSC-derived islets (iPSC islets), however, remain limited by scalability and …

Human induced pluripotent stem cells (hiPSCs) can give rise to multiple lineages derived
from three germ layers, endoderm, mesoderm and ectoderm. Definitive endoderm (DE) cell …

Induced pluripotent stem cell (iPSC)-derived T (iT) cells represent a groundbreaking frontier
in adoptive cell therapies with engineered T cells, poised to overcome pivotal limitations …

Generation of pure pancreatic progenitor (PP) cells is critical for clinical translation of stem
cell-derived islets. Herein, we performed PP differentiation with and without AKT/P70 …

Given the demands human induced pluripotent stem cell (hiPSC)-based therapeutics place
on manufacturing, process intensification strategies which rapidly ensure the desired cell …

Advanced protocols to produce human pluripotent stem cell (SC)-derived islets show
promise in functional, metabolic, and transcriptional maturation of cell therapy product to …