Circulating tumor cells: biology and clinical significance
D Lin, L Shen, M Luo, K Zhang, J Li, Q Yang… - Signal transduction and …, 2021 - nature.com
Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …
Aptamer-based detection of circulating targets for precision medicine
L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …
Tracking the evolution of non–small-cell lung cancer
Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective …
heterogeneity and cancer genome evolution have been limited to small retrospective …
Biology, vulnerabilities and clinical applications of circulating tumour cells
In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …
Tumour heterogeneity and metastasis at single-cell resolution
Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic
properties that can differentially promote progression, metastasis and drug resistance …
properties that can differentially promote progression, metastasis and drug resistance …
EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Single-cell genome sequencing: current state of the science
The field of single-cell genomics is advancing rapidly and is generating many new insights
into complex biological systems, ranging from the diversity of microbial ecosystems to the …
into complex biological systems, ranging from the diversity of microbial ecosystems to the …
Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas
Single-cell genome, DNA methylome, and transcriptome sequencing methods have been
separately developed. However, to accurately analyze the mechanism by which …
separately developed. However, to accurately analyze the mechanism by which …
Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer
CL Hodgkinson, CJ Morrow, Y Li, RL Metcalf… - Nature medicine, 2014 - nature.com
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor with early
dissemination and dismal prognosis, accounts for 15–20% of lung cancer cases and∼ …
dissemination and dismal prognosis, accounts for 15–20% of lung cancer cases and∼ …
Advances and applications of single-cell sequencing technologies
Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for
studying rare cells and delineating complex populations. Over the past 5 years, SCS …
studying rare cells and delineating complex populations. Over the past 5 years, SCS …