Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease

KE Bohnsack, C Höbartner, MT Bohnsack - Genes, 2019 - mdpi.com
5-methylcytosine (m5C) is an abundant RNA modification that's presence is reported in a
wide variety of RNA species, including cytoplasmic and mitochondrial ribosomal RNAs …

Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout/mutated mice

SY Jiao, YH Yang, SR Chen - Human reproduction update, 2021 - academic.oup.com
BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

[HTML][HTML] Zinc is an essential element for male fertility: a review of Zn roles in men's health, germination, sperm quality, and fertilization

A Fallah, A Mohammad-Hasani… - Journal of reproduction & …, 2018 - ncbi.nlm.nih.gov
Zinc (Zn) is the second most abundant trace element in human, which can't be stored in the
body, thus regular dietary intake is required. This review explained the physiological and …

5-methylcytosine RNA methyltransferases and their potential roles in cancer

M Li, Z Tao, Y Zhao, L Li, J Zheng, Z Li… - Journal of translational …, 2022 - Springer
Abstract In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key
player in regulating RNA metabolism and function through coding as well as non-coding …

NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization

J Su, G Wu, Y Ye, J Zhang, L Zeng, X Huang, Y Zheng… - Oncogene, 2021 - nature.com
Methylcytosine (m5C) is a posttranscriptional RNA modification participating in many critical
bioprocesses, but its functions in human cancer remain unclear. Here, by detecting the …

RNA modification: mechanisms and therapeutic targets

L Qiu, Q **g, Y Li, J Han - Molecular Biomedicine, 2023 - Springer
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

Integrative analyses of the RNA modification machinery reveal tissue-and cancer-specific signatures

O Begik, MC Lucas, H Liu, JM Ramirez, JS Mattick… - Genome biology, 2020 - Springer
Background RNA modifications play central roles in cellular fate and differentiation.
However, the machinery responsible for placing, removing, and recognizing more than 170 …

Post-transcriptional regulation by cytosine-5 methylation of RNA

R García-Vílchez, A Sevilla, S Blanco - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
The recent advent of high-throughput sequencing technologies coupled with RNA
modifications detection methods has allowed the detection of RNA modifications at single …

Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6

RJ Liu, T Long, J Li, H Li, ED Wang - Nucleic acids research, 2017 - academic.oup.com
methylcytosine (m5C) modifications of RNA are ubiquitous in nature and play important
roles in many biological processes such as protein translational regulation, RNA processing …

Identification and validation of key biomarkers based on RNA methylation genes in sepsis

Q Zhang, X Bao, M Cui, C Wang, J Ji, J **g… - Frontiers in …, 2023 - frontiersin.org
Background RNA methylation is closely involved in immune regulation, but its role in sepsis
remains unknown. Here, we aim to investigate the role of RNA methylation-associated …