Applications and evolution of melittin, the quintessential membrane active peptide

S Guha, RP Ferrie, J Ghimire, CR Ventura, E Wu… - Biochemical …, 2021 - Elsevier
Melittin, the main venom component of the European Honeybee, is a cationic linear peptide-
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …

[HTML][HTML] Ellagic acid alleviates oxidative stress by mediating Nrf2 signaling pathways and protects against paraquat-induced intestinal injury in piglets

Y **ao, R Huang, N Wang, Y Deng, B Tan, Y Yin, M Qi… - Antioxidants, 2022 - mdpi.com
The gastrointestinal tract is a key source of superoxide so as to be one of the most
vulnerable to oxidative stress damage. Ellagic acid (EA), a polyphenol displays widely …

The herbicide paraquat-induced molecular mechanisms in the development of acute lung injury and lung fibrosis

R Subbiah, RR Tiwari - Critical Reviews in Toxicology, 2021 - Taylor & Francis
Abstract The herbicide paraquat (PQ; 1, 1'-dimethyl-4, 4'-bipyridylium dichloride) is a highly
toxic organic heterocyclic herbicide that has been widely used in agricultural settings. Since …

Apilarnil ameliorates Bisphenol A-induced testicular toxicity in adult male rats via improving antioxidant potency and PCNA expression

MH Elashal, AA Abd El-Wahed, MA Mohamed… - Reproductive …, 2024 - Elsevier
Apilarnil, a bee-derived product originating from drone larvae, offers a range of
advantageous properties for both humans and animals. It functions as an antioxidant …

Bee venom and its active component Melittin synergistically potentiate the anticancer effect of Sorafenib against HepG2 cells

GH Mansour, MA El-Magd, DH Mahfouz… - Bioorganic …, 2021 - Elsevier
There are current attempts to find a safe substitute or adjuvant for Sorafenib (Sorf), the
standard treatment for advanced hepatocellular carcinoma (HCC), as it triggers very harsh …

Improvement of inhaled paraquat induced lung and systemic inflammation, oxidative stress and memory changes by safranal

S Beigoli, AA Hajizadeh, MET Yazdi, R Khosravi… - Toxicon, 2024 - Elsevier
The effects of safranal and pioglitazone alone and their combination on inhaled paraquat
(PQ)-induced systemic oxidative stress and inflammation as well as behavioral changes …

Melittin and diclofenac synergistically promote wound healing in a pathway involving TGF-β1

BG Eid, NA Alhakamy, UA Fahmy, OAA Ahmed… - Pharmacological …, 2022 - Elsevier
A dysregulation of the wound healing process can lead to the development of various
intractable ulcers or excessive scar formation. Therefore it is essential to identify novel …