Immunotherapy has been a remarkable clinical advancement in the treatment of cancer. T
cells are pivotal to the efficacy of current cancer immunotherapies, including immune …

Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion,
which is characterized by reduced effector function and proliferation, and the expression of …

T cell exhaustion limits antitumor immunity, but the molecular determinants of this process
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …

A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is
underway. Originally thought to be a uniform population that progressively loses effector …

Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Artificial intelligence and machine learning techniques are breaking into biomedical
research and health care, which importantly includes cancer research and oncology, where …

Abstract Anti–PD-1/PD-L1 immune checkpoint blockade (ICB) therapy has revolutionized
the treatment of many types of cancer over the past decade. The initial therapeutic …

T cell exhaustion is a major impediment to antitumor immunity. However, it remains elusive
how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional …

Clinical response to adoptive T cell therapies is associated with the transcriptional and
epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and …

T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …