Current and future treatments for Alzheimer's disease

KG Yiannopoulou… - Therapeutic advances in …, 2013 - journals.sagepub.com
Alzheimer's dementia (AD) is increasingly being recognized as one of the most important
medical and social problems in older people in industrialized and non-industrialized …

Alzheimer's disease: a review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment

P dos Santos, C Leide, PF Ozela… - Current medicinal …, 2018 - ingentaconnect.com
Dementia is characterized by the impairment of cognition and behavior of people over 65
years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the …

Antipsychotic use in dementia: a systematic review of benefits and risks from meta-analyses

RR Tampi, DJ Tampi… - … advances in chronic …, 2016 - journals.sagepub.com
Background: The purpose of this review is to evaluate the data on the use of antipsychotics
in individuals with dementia from meta-analyses. Methods: We performed a literature search …

Lack of evidence for the efficacy of memantine in mild Alzheimer disease

LS Schneider, KS Dagerman, JPT Higgins… - Archives of …, 2011 - jamanetwork.com
Objective We directly assessed the clinical trials' evidence for memantine's efficacy in mild
Alzheimer disease (AD). Memantine is indicated in the United States and Europe for …

Current and emerging drug treatment options for Alzheimer's disease: a systematic review

N Herrmann, SA Chau, I Kircanski, KL Lanctot - Drugs, 2011 - Springer
Alzheimer's disease (AD) is a progressive and ultimately fatal condition that causes
debilitating memory loss and extensive deterioration of cognitive and functional abilities …

Dementia is more than memory loss: neuropsychiatric symptoms of dementia and their nonpharmacological and pharmacological management

RR Tampi, DV Jeste - American Journal of Psychiatry, 2022 - Am Psychiatric Assoc
Neuropsychiatric symptoms of dementia (NPS) are a group of noncognitive symptoms that
occur in over 90% of individuals with dementia. NPS seem to result from a complex …

Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis

R Chen, PT Chan, H Chu, YC Lin, PC Chang… - PloS one, 2017 - journals.plos.org
Background This is the first meta-analysis to compare the treatment effects and safety of
administering donepezil alone versus a combination of memantine and donepezil to treat …

Depression in Alzheimer's disease: epidemiology, mechanisms, and management

S Chi, JT Yu, MS Tan, L Tan - Journal of Alzheimer's disease, 2014 - content.iospress.com
Depression occurs with a high prevalence of up to 50% in patients with Alzheimer's disease
(AD) and increases the caregivers' burden. Depression symptoms can precede clinical …

Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer's disease neuropathology

MF Hossain, N Wang, R Chen, S Li, J Roy… - Ageing Research …, 2021 - Elsevier
Melatonin (MLT) is a neurohormone that is regulated by the circadian clock and plays
multifunctional roles in numerous neurodegenerative disorders, such as Alzheimer's …

Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia

N Hishikawa, Y Takahashi, Y Amakusa… - AYU (An international …, 2012 - journals.lww.com
We describe here three patients with the Alzheimer's Disease (AD) whose behavioral
symptoms were improved remarkably as a result of the turmeric treatment, which is the …