We discuss the genetic, demographic, and selective forces that are likely to be at play in
restricting observed levels of DNA sequence variation in natural populations to a much …

Dominance refers to the effect of a heterozygous genotype relative to that of the two
homozygous genotypes. The degree of dominance of mutations for fitness can have a …

Understanding how populations adapt to abrupt environmental change is necessary to
predict responses to future challenges, but identifying specific adaptive variants, quantifying …

Current procedures for inferring population history generally assume complete neutrality—
that is, they neglect both direct selection and the effects of selection on linked sites. We here …

Background selection is a process whereby recurrent deleterious mutations cause a
decrease in the effective population size and genetic diversity at linked loci. Several authors …

As a genetic mutation is passed down across generations, it distinguishes those genomes
that have inherited it from those that have not, providing a glimpse of the genealogical tree …

It is increasingly evident that natural selection plays a prominent role in sha** patterns of
diversity across the genome. The most commonly studied modes of natural selection are …

Inferring the effects of positive selection on genomes remains a critical step in characterizing
the ultimate and proximate causes of adaptation across species, and quantifying positive …

Neutral genetic diversity across the genome is determined by the complex interplay of
mutation, demographic history, and natural selection. While the direct action of natural …

A major research goal in evolutionary genetics is to uncover loci experiencing positive
selection. One approach involves finding 'selective sweeps' patterns, which can either be …