The increased incidence of inflammatory bowel disease (IBD) has seriously affected the life
quality of patients. IBD develops due to excessive intestinal epithelial cell (IEC) apoptosis …

For decades, the therapeutic goal of conventional treatment among inflammatory bowel
disease (IBD) patients is alleviating exacerbations in acute phase, maintaining remission …

Colorectal cancer is a known complication of chronic inflammation of the colon (“colitis-
associated colon cancer”). Inflammatory bowel disease (IBD) is a chronic inflammatory …

The intestinal epithelium ensures uptake of vital nutrients and acts as a barrier between
luminal contents and the underlying immune system. In inflammatory bowel diseases, such …

Metabolomics is an emerging field involving the systematic identification and quantification
of numerous metabolites in biological samples. Precision medicine applies multiomics …

Janus kinase (JAK), a class of non-receptor tyrosine kinases, are essential in modulating the
cytokine signaling cascade of cytokines associated with immune responses. Despite their …

Inflammatory bowel disease (IBD) is a chronic disorder with an increasing global
prevalence. Managing disease activity relies on various pharmacological options. However …

Background The treatment of Crohn's disease (CD) has received widespread attention in
clinical practice, but there is currently a lack of quantitative evaluation of the literature …

Background Ulcerative colitis (UC) is a chronic immune-mediated inflammation of the
colorectum, for which infliximab (IFX) is currently the mainstay of treatment. However, one …

Background Targeted agents are widely utilized in the treatment of ulcerative colitis (UC).
Hence, a comprehensive understanding of comparative drug efficacy in UC is of great …