Emerging targets in photopharmacology
The field of photopharmacology uses molecular photoswitches to establish control over the
action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of …
action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of …
The role of calcium–calcineurin–NFAT signaling pathway in health and autoimmune diseases
Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …
functions. In the immune system, calcium signals play a central role in a variety of cellular …
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
Transient receptor potential (TRP) channels are sensors for a wide range of cellular and
environmental signals, but elucidating how these channels respond to physical and …
environmental signals, but elucidating how these channels respond to physical and …
TRPV1 structures in distinct conformations reveal activation mechanisms
Transient receptor potential (TRP) channels are polymodal signal detectors that respond to
a wide range of physical and chemical stimuli. Elucidating how these channels integrate and …
a wide range of physical and chemical stimuli. Elucidating how these channels integrate and …
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …
conditionally conduct small and large cations. Such functional plasticity is presumably …
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs
Abstract SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy
inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are …
inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are …
Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses
In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …
Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch
P Anand, K Bley - British journal of anaesthesia, 2011 - academic.oup.com
Topical capsaicin formulations are used for pain management. Safety and modest efficacy of
low-concentration capsaicin formulations, which require repeated daily self-administration …
low-concentration capsaicin formulations, which require repeated daily self-administration …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
A pentameric TRPV3 channel with a dilated pore
Transient receptor potential (TRP) channels are a large, eukaryotic ion channel superfamily
that control diverse physiological functions, and therefore are attractive drug targets,,,–. More …
that control diverse physiological functions, and therefore are attractive drug targets,,,–. More …