The limited armamentarium against drug-resistant Gram-negative bacilli has led to the
development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Carbapenem resistance is a major global health problem that seriously compromises the
treatment of infections caused by nosocomial pathogens. Resistance to carbapenems …

ABSTRACT From January 2019 to April 2020, 32 KPC-producing, ceftazidime-avibactam
(CZA)-resistant Klebsiella pneumoniae strains were isolated in a university hospital in …

Azepanes or azepines are structural motifs of many drugs, drug candidates and evaluated
lead compounds. Even though compounds having N-heterocyclic 7-membered rings are …

Serial femtosecond crystallography has opened up many new opportunities in structural
biology. In recent years, several approaches employing light-inducible systems have …

Objectives In order to inform and anticipate potential strategies aimed at combating KPC-
producing Klebsiella pneumoniae infections, we analysed imipenem/relebactam and …

Bacterial resistance mechanisms are continuously and rapidly evolving. This is particularly
true for Gram-negative bacteria. Over the last decade, the strategy to develop new β …

Protein structure (and thus function) is dictated by non‐covalent interaction networks. These
can be highly evolutionarily conserved across protein families, the members of which can …

Imipenem-relebactam (IR) is a novel beta-lactam/beta-lactamase inhibitor combination
given with cilastatin. It is indicated for the treatment of complicated urinary tract infections …