Quiescence is a state of reversible proliferative arrest in which cells are not actively dividing
and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus …

Quiescence is a cellular state in which a cell remains out of the cell cycle but retains the
capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for …

Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

INTRODUCTION The chromosome breakage-fusion-bridge (BFB) cycle is a catastrophic
mutational process, common during tumorigenesis, that results in gene amplification and …

Female fertility is inversely correlated with maternal age due to a depletion of the oocyte
pool and a reduction in oocyte developmental competence. Few studies have addressed the …

Although originally thought to be silent chromosomal regions, centromeres are instead
actively transcribed. However, the behavior and contributions of centromere-derived RNAs …

The kinetochore plays an essential role in facilitating chromosome segregation during cell
division. This massive protein complex assembles onto the centromere of chromosomes and …

Pollen development and germination are critical for successful generation of offspring in
plants, yet they are highly susceptible to heat stress (HS). However, the molecular …

Cellular quiescence–reversible exit from the cell cycle–is an important feature of many cell
types important for organismal health. Aging and cellular dysfunction compromise the …

Centromeric transcription has been shown to play an important role in centromere functions.
However, lack of approaches to specifically manipulate centromeric transcription calls into …