Tailor-made polysaccharides for biomedical applications

M Khodadadi Yazdi, F Seidi, A Hejna… - ACS Applied Bio …, 2024 - ACS Publications
Polysaccharides (PSAs) are carbohydrate-based macromolecules widely used in the
biomedical field, either in their pure form or in blends/nanocomposites with other materials …

Harnessing the power of bee venom for therapeutic and regenerative medical applications: an updated review

KM Sadek, NA Shib, ES Taher, F Rashed… - Frontiers in …, 2024 - frontiersin.org
Honeybees have been helpful insects since ancient centuries, and this benefit is not limited
to being a honey producer only. After the bee stings a person, pain, and swelling occur in …

Recent advances in the development and application of peptide self-assemblies in infection control

T Ge, X Hu, M Liao, F Zhou, JR Lu - Current Opinion in Colloid & Interface …, 2023 - Elsevier
Peptide self-assemblies display distinct physical and structural transitions, featured from the
early small assemblies or oligomers, long nanosheets, nanobelts, nanotubes and …

Interaction of designed cationic antimicrobial peptides with the outer membrane of gram-negative bacteria

S He, CM Deber - Scientific Reports, 2024 - nature.com
The outer membrane (OM) is a hallmark feature of gram-negative bacteria that provides the
species with heightened resistance against antibiotic threats while cationic antimicrobial …

Exploring the mechanism of photosensitizer conjugation on membrane perturbation of antimicrobial peptide: A multiscale molecular simulation study

Y Liu, M Song, J Wu, S **e, Y Zhou, L Liu… - International Journal of …, 2023 - Elsevier
Antimicrobial peptides (AMPs) exert their biological functions by perturbation with cellular
membrane. Conjugation of AMPs with photosensitizer (PS) is a promising strategy for …

[HTML][HTML] Combination of a pH-responsive peptide amphiphile and a conventional antibiotic in treating Gram-negative bacteria

M Liao, H Gong, H Liu, K Shen, T Ge, S King… - Journal of Colloid and …, 2024 - Elsevier
Background Clinical treatments of gastric infections using antibiotics suffer from the
undesired killing of commensal bacteria and emergence of antibiotic resistance. It is …

Engineering the interaction of short antimicrobial peptides with bacterial barriers

C Montis, E Marelli, F Valle, FB Bombelli… - … Systems Design & …, 2024 - pubs.rsc.org
While the rise of superbugs and new resistance mechanisms continues decreasing the
effectiveness of classical antibiotics, antimicrobial peptides (AMPs) are emerging as a new …

Advances in the clinical treatment of multidrug-resistant pathogens using polymyxins

Y Huang, M Liao, X Hu, H Hu… - Journal of Antimicrobial …, 2024 - academic.oup.com
Objectives Polymyxins are a vital class of antibiotics used to combat multidrug-resistant
Gram-negative bacteria. However, their use is limited due to potential nephrotoxicity and the …

Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses

A Chianese, C Zannella, A Monti, N Doti… - International Journal of …, 2023 - mdpi.com
Pandemic and epidemic outbreaks of respiratory viruses are a challenge for public health
and social care system worldwide, leading to high mortality and morbidity among the human …

[HTML][HTML] The limits of prediction: Why intrinsically disordered regions challenge our understanding of antimicrobial peptides

R Bello-Madruga, MT Burgas - Computational and Structural Biotechnology …, 2024 - Elsevier
Antimicrobial peptides (AMPs) are molecules found in most organisms, playing a vital role in
innate immune defense against pathogens. Their mechanism of action involves the …