Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

The permeability barrier imposed by cellular membranes limits the access of exogenous
compounds to the interior of cells. Researchers and patients alike would benefit from …

In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …

The emergence of new pathogens and multidrug resistant bacteria is an important public
health issue that requires the development of novel classes of antibiotics. Antimicrobial …

Peptides are emerging as a new tool in drug and gene delivery. Peptide-drug conjugates
and peptide-modified drug delivery systems provide new opportunities to avoid macrophage …

Biomolecules such as antibodies, proteins, and peptides are important tools for chemical
biology and leads for drug development. They have been used to inhibit a variety of …

The membrane transport mechanisms of cell-penetrating peptides (CPPs) are still
controversial, and reliable assays to report on their internalization in model membranes are …

Macrocyclic peptides open new opportunities to target intracellular protein–protein
interactions (PPIs) that are often considered nondruggable by traditional small molecules …

Lipid bilayer membranes are often represented as a continuous nonpolar slab with a certain
thickness bounded by two more polar interfaces. Phenomena such as peptide binding to the …

How can highly charged, cationic antimicrobial peptides (AMPs) translocate across
hydrophobic lipid bilayers despite the prohibitive energetic penalty to do so? A common …