Cumulus cells (CCs) originating from undifferentiated granulosa cells (GCs) differentiate in
mural granulosa cells (MGCs) and CCs during antrum formation in the follicle by the …

BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Oocyte in vitro maturation (IVM) is an assisted reproductive technology with a long and
sometimes checked history. It is a minimally invasive technique involving the deliberate …

Infertility affects~ 7% of couples of reproductive age with little change in incidence in the last
two decades. ART, as well as other interventions, have made major strides in correcting this …

Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

An equilibrium needs to be established by the cellular and acellular components of the
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …

BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

Background Oocyte growth is accompanied by follicular development in mammalian
ovaries. Since the discovery of two oocyte‐derived factors, growth differentiation factor 9 …

The ovary is the first organ to age in humans with functional decline evident already in
women in their early 30s. Reproductive aging is characterized by a decrease in oocyte …