Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …
Early diagnosis of Alzheimer's disease: contribution of structural neuroimaging
G Aël Chetelat, JC Baron - Neuroimage, 2003 - Elsevier
To accurately predict the development of Alzheimer's disease (AD) at its predementia stage
would be a major breakthrough from both therapeutic and research standpoints. In this …
would be a major breakthrough from both therapeutic and research standpoints. In this …
Vascular dysfunction—the disregarded partner of Alzheimer's disease
Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …
Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience
NA Johnson, GH Jahng, MW Weiner, BL Miller… - Radiology, 2005 - pubs.rsna.org
PURPOSE: To prospectively determine if pulsed arterial spin-labeling perfusion magnetic
resonance (MR) imaging depicts regional cerebral hypoperfusion in subjects with Alzheimer …
resonance (MR) imaging depicts regional cerebral hypoperfusion in subjects with Alzheimer …
3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease
JL Whitwell, SA Przybelski, SD Weigand, DS Knopman… - Brain, 2007 - academic.oup.com
Mild cognitive impairment (MCI), particularly the amnestic subtype (aMCI), is considered as
a transitional stage between normal aging and a diagnosis of clinically probable Alzheimer's …
a transitional stage between normal aging and a diagnosis of clinically probable Alzheimer's …
FDG-PET as an independent biomarker for Alzheimer's biological diagnosis: a longitudinal study
YN Ou, W Xu, JQ Li, Y Guo, M Cui, KL Chen… - Alzheimer's research & …, 2019 - Springer
Background Reduced 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET)
brain metabolism was recognized as a biomarker of neurodegeneration in the recently …
brain metabolism was recognized as a biomarker of neurodegeneration in the recently …
Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy
Alzheimer's disease (AD) is characterized by a heterogeneous distribution of pathological
changes throughout the brain. Magnetic resonance imaging can be used to investigate the …
changes throughout the brain. Magnetic resonance imaging can be used to investigate the …
MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study
Background: Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins,
are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine …
are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine …
Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease
Y Chen, DA Wolk, JS Reddin, M Korczykowski… - Neurology, 2011 - AAN Enterprises
Objective: We compared the ability of arterial spin labeling (ASL), an MRI method that
measures cerebral blood flow (CBF), to that of FDG-PET in distinguishing patients with …
measures cerebral blood flow (CBF), to that of FDG-PET in distinguishing patients with …
Voxel-based map** of brain gray matter volume and glucose metabolism profiles in normal aging
With age, the brain undergoes both structural and functional alterations, probably resulting
in reported cognitive declines. Relatively few investigations have sought to identify those …
in reported cognitive declines. Relatively few investigations have sought to identify those …