Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Neuroinflammation is instigated by the misfiring of immune cells in the central nervous
system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a …

The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …

The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve
fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic …

The TRPM (transient receptor potential melastatin) family belongs to the superfamily of TRP
cation channels. The TRPM subfamily is composed of eight members that are involved in …

Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

INTRODUCTION Transient receptor potential melastatin member 8 (TRPM8) is a calcium-
permeable ion channel that serves as the principal detector of cold in humans. Natural and …

Different cell channels and transporters tightly regulate cytoplasmic levels and the
intraorganelle distribution of cations. Perturbations in these processes lead to human …

Praziquantel (PZQ) is an essential medicine for treating parasitic flatworm infections such as
schistosomiasis, which afflicts over 250 million people. However, PZQ is not universally …

The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary detector of
environmental cold and an important target for treating pathological cold hypersensitivity …