Conventional cancer chemotherapy is seriously limited by the multidrug resistance (MDR)
commonly exhibited by tumour cells. One mechanism by which a living cell can achieve …

The resistance of tumor cells to anticancer agents remains a major cause of treatment failure
in cancer patients. The term multidrug resistance (MDR) is used to define a resistance …

Abstract Treatment of human prostate carcinoma‐derived LNCaP cells with androgen or
oestradiol triggers simultaneous association of androgen receptor and oestradiol receptor β …

The p85-associated phosphatidylinositol (PI) 3-kinase/Akt pathway mediates the oestradiol-
induced S-phase entry and cyclin D1 promoter activity in MCF-7 cells. Experiments with Src …

Mammalian vaults are ribonucleoprotein (RNP) complexes, composed of a small ribonucleic
acid and three proteins of 100, 193, and 240 kD in size. The 100-kD major vault protein …

E2 rapidly activates MAPK in breast cancer cells, and the mechanism for this effect has not
been fully identified. Since growth factor-induced MAPK activation involves signaling via the …

An immediate cellular response to DNA damage is the synthesis of poly (ADP-ribose) by the
enzyme poly (ADP-ribose) polymerase (PARP). This nuclear enzyme and the unique post …

Vaults are ribonucleoprotein particles found in the cytoplasm of eucaryotic cells. The 13
MDa particles are composed of multiple copies of three proteins: an M r 100 000 major vault …

Purpose: This study investigated the cellular distribution of different multidrug resistance
(MDR)‐related proteins such as P‐glycoprotein (P‐gp), the multidrug resistance–associated …

Tumor cells that are insensitive to anticancer drugs frequently have a multidrug-resistant
(MDR) phenotype. Proteins that can be involved in this phenomenon are transport …